Stachydrine Alleviates Sepsis-Induced Cardiomyopathy by Inhibiting Ferroptosis via Regulating SIRT1/GPX4 Pathway
Sign Up to like & getrecommendations! Published in 2025 at "Dose-Response"
DOI: 10.1177/15593258251377710
Abstract: Objectives This study investigated the cardioprotective effects of stachydrine (STA) in lipopolysaccharide (LPS)-induced septic mice and H9c2 cardiomyocytes, focusing on its anti-apoptotic, anti-inflammatory, and anti-ferroptotic actions. Methods We established an LPS-induced sepsis model in mice… read more here.
Keywords: gpx4 pathway; ferroptosis; sirt1 gpx4; lps induced ... See more keywords
Danshen injection ameliorates unilateral ureteral obstruction-induced renal fibrosis by inhibiting ferroptosis via activating SIRT1/GPX4 pathway
Sign Up to like & getrecommendations! Published in 2025 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2024.1503628
Abstract: Introduction The pathogenesis of renal fibrosis is related to blood stasis, and the method of promoting blood circulation and removing blood stasis is often used as the treatment principle. Danshen injection (DSI) is a commonly… read more here.
Keywords: fibrosis; renal fibrosis; dsi; ferroptosis ... See more keywords