Nicotinamide phosphoribosyl transferase regulates cell growth via the Sirt1/P53 signaling pathway and is a prognosis marker in colorectal cancer
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.27228
Abstract: Colorectal cancer (CRC) is the third most common malignancy, and the metabolic properties of CRC cells include enhanced aerobic glycolysis (the Warburg effect). Nicotinamide phosphoribosyl transferase (NAMPT) is one of the crucial enzymes that regulate… read more here.
Keywords: cell growth; sirt1 p53; colorectal cancer; crc ... See more keywords
Protective effect of astaxanthin against contrast-induced acute kidney injury via SIRT1-p53 pathway in rats
Sign Up to like & getrecommendations! Published in 2018 at "International Urology and Nephrology"
DOI: 10.1007/s11255-018-2027-2
Abstract: PurposeThe present study was designed to further investigate the protective effect of astaxanthin (AST) on contrast-induced acute kidney injury (CI-AKI) in rats and the relationship between SIRT1-p53 pathway and astaxanthin.Methods40 adult male Sprague Dawley (SD)… read more here.
Keywords: protective effect; group; p53; sirt1 p53 ... See more keywords
Role of Sirtuin1-p53 regulatory axis in aging, cancer and cellular reprogramming
Sign Up to like & getrecommendations! Published in 2018 at "Ageing Research Reviews"
DOI: 10.1016/j.arr.2018.02.004
Abstract: Regulatory role of Sirtuin 1 (SIRT1), one of the most extensively studied members of its kind in histone deacetylase family in governing multiple cellular fates, is predominantly linked to p53 activity. SIRT1 deacetylates p53 in… read more here.
Keywords: regulatory axis; role; cancer; p53 ... See more keywords
MiR-34a/Sirt1/p53 signaling pathway contributes to cadmium-induced nephrotoxicity: A preclinical study in mice.
Sign Up to like & getrecommendations! Published in 2021 at "Environmental pollution"
DOI: 10.1016/j.envpol.2021.117029
Abstract: Cadmium (Cd), as an environmental pollutant, can lead to nephrotoxicity. However, its nephrotoxicological mechanisms have not been fully elucidated. In this study, Cd (1.5 mg/kg body weight, gavaged for 4 weeks) was found to induce the… read more here.
Keywords: sirt1 p53; mir 34a; nephrotoxicity; 34a sirt1 ... See more keywords
The Sirt1/P53 Axis in Diabetic Intervertebral Disc Degeneration Pathogenesis and Therapeutics
Sign Up to like & getrecommendations! Published in 2019 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2019/7959573
Abstract: Intervertebral disc degeneration (IDD) is one of the major causes of low back pain. Diabetes is a risk factor for IDD and may aggravate IDD in rats; however, the mechanism is poorly understood. Previously, we… read more here.
Keywords: apoptosis senescence; p53 axis; intervertebral disc; p53 ... See more keywords
Inflammasome activation and pyroptosis via a lipid-regulated SIRT1-p53-ASC axis in macrophages from male mice and humans.
Sign Up to like & getrecommendations! Published in 2022 at "Endocrinology"
DOI: 10.1210/endocr/bqac014
Abstract: Obesity-linked diabetes is associated with accumulation of pro-inflammatory macrophages into adipose tissue leading to inflammasome activation and pyroptotic secretion of IL-1β and IL-18. Targeting fatty acid binding protein 4 (FABP4) uncouples obesity from inflammation, attenuates… read more here.
Keywords: inflammasome activation; p53; activation; sirt1 p53 ... See more keywords
Antioxidant Effects of Sophora davidi (Franch.) Skeels on d–Galactose–Induced Aging Model in Mice via Activating the SIRT1/p53 Pathway
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2021.754554
Abstract: This study investigated the protective effect of Sophora davidi (Franch.) Skeels fruits extract (SDE) on d–galactose–induced acute aging in mice. Ultra performance liquid chromatography coupled with tine-of-flight mass spectrometry (UPLC-Q-TOF/MS) was performed to identify the… read more here.
Keywords: liver brain; expression; sirt1 p53; brain ... See more keywords
KLF4 downregulates FGF21 to activate inflammatory injury and oxidative stress of LPS-induced ATDC5 cells via SIRT1/NF-κB/p53 signaling
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Medicine Reports"
DOI: 10.3892/mmr.2022.12680
Abstract: Ankylosing spondylitis (AS) is a chronic inflammatory disease. Transcriptional regulation of fibroblast growth factor 21 (FGF21) by the transcription factor Krüppel-like factor 4 (KLF4) serves an important role in chronic inflammatory disease. However, to the… read more here.
Keywords: inflammatory injury; sirt1 p53; oxidative stress; lps induced ... See more keywords