Apoptotic extracellular vesicles alleviate Pg-LPS induced inflammation of macrophages via AMPK/SIRT1/NF-κB pathway and inhibit adjacent osteoclasts formation.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of periodontology"
DOI: 10.1002/jper.21-0657
Abstract: BACKGROUND Periodontitis is caused by the imbalance of anti-bacteria immune response and excessive inflammation whereas macrophages play an important role in inflammation. Thus, it is critical for finding efficient anti-inflammatory strategies to alleviate periodontal inflammation… read more here.
Keywords: inflammation; sirt1 pathway; ampk sirt1; osteoclasts formation ... See more keywords
SLAB51 Probiotic Formulation Activates SIRT1 Pathway Promoting Antioxidant and Neuroprotective Effects in an AD Mouse Model
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Neurobiology"
DOI: 10.1007/s12035-018-0973-4
Abstract: The gut-brain axis is a bidirectional communication network functionally linking the gut and the central nervous system (CNS). Based on this, the rational manipulation of intestinal microbiota represents a novel attractive therapeutic strategy for the… read more here.
Keywords: activates sirt1; formulation activates; formulation; probiotic formulation ... See more keywords
Gypenosides regulate autophagy through Sirt1 pathway and the anti-inflammatory mechanism of mitochondrial autophagy in systemic lupus erythematosus
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineered"
DOI: 10.1080/21655979.2022.2066749
Abstract: ABSTRACT To study the mechanism of gynostemma pentaphyllum saponins (GpS) regulating mitochondrial autophagy and anti-inflammatory through Sirtuin 1 (Sirt1) pathway in systemic lupus erythematosus (SLE). JURKAT cells were cultured in vitro, RT-PCR and western blotting… read more here.
Keywords: sirt1 pathway; gps; mechanism; lupus ... See more keywords
Resveratrol Mitigates High-Fat Diet–Induced Vascular Dysfunction by Activating the Akt/eNOS/NO and Sirt1/ER Pathway
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cardiovascular Pharmacology"
DOI: 10.1097/fjc.0000000000000621
Abstract: Abstract: We investigated whether resveratrol (RSV) can attenuate obesity and diabetes progression and improve diabetes-induced vascular dysfunction, and we attempted to delineate its underlying mechanisms. Male C57Bl/6 mice were administered a high-fat diet (HFD) for… read more here.
Keywords: rsv; sirt1 pathway; vascular dysfunction; induced vascular ... See more keywords
Bushen Huoxue Formula Modulates Autophagic Flux and Inhibits Apoptosis to Protect Nucleus Pulposus Cells by Restoring the AMPK/SIRT1 Pathway
Sign Up to like & getrecommendations! Published in 2022 at "BioMed Research International"
DOI: 10.1155/2022/8929448
Abstract: Background Low back pain (LBP) has the characteristics of chronic and persistence, which is a heavy social burden. Intervertebral disc degeneration (IVDD) is a major cause of LBP. The typical features of IVDD are extracellular… read more here.
Keywords: cell; apoptosis; sirt1 pathway; ampk sirt1 ... See more keywords
Astragaloside IV Alleviates Atorvastatin-Induced Hepatotoxicity via AMPK/SIRT1 Pathway
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DOI: 10.1159/000527231
Abstract: Introduction: Atorvastatin (ATO) is often used to reduce blood lipids and prevent atherosclerosis, but excessive use of ATO will lead to hepatotoxicity. This paper investigated the effects of astragaloside IV (AS IV), which has multiple… read more here.
Keywords: ato induced; sirt1 pathway; ampk sirt1; hepatotoxicity ... See more keywords
Candidate oncogene circularNOP10 mediates gastric cancer progression by regulating miR-204/SIRT1 pathway.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of gastrointestinal oncology"
DOI: 10.21037/jgo-21-422
Abstract: Background The role of circular RNA (circRNA) in gastric cancer (GC) is attracting increasing attention. CircNOP10 (hsa_circ-0034351) has been reported to be upregulated in human GC tissue. However, the biological role and mechanism of circNOP10… read more here.
Keywords: circnop10; gastric cancer; 204 sirt1; sirt1 pathway ... See more keywords
Salvianolic Acid A Protects against Acetaminophen-Induced Hepatotoxicity via Regulation of the miR-485-3p/SIRT1 Pathway
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DOI: 10.3390/antiox12040870
Abstract: The vast majority of drug-induced liver injury is mainly attributed to acetaminophen (APAP) overdose. Salvianolic acid A (Sal A), a powerful water-soluble compound obtained from Salvia miltiorrhiza, has been confirmed to exert hepatoprotective effects. However,… read more here.
Keywords: sirt1 pathway; 485 sirt1; hepatotoxicity; salvianolic acid ... See more keywords