Tropisetron restores normal expression of BAD, SIRT1, SIRT3, and SIRT7 in the rat pressure overload-induced cardiac hypertrophy model.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of biochemical and molecular toxicology"
DOI: 10.1002/jbt.23355
Abstract: Tropisetron exerts a protective effect against cardiac complications, particularly cardiac hypertrophy. Oxidative stress and apoptosis are the main contributors to the pathogenesis of cardiac hypertrophy. Sirtuins, a family of histone deacetylases, are connected to cellular… read more here.
Keywords: hypertrophy; sirt1 sirt3; expression; cardiac hypertrophy ... See more keywords
Ramadan diurnal intermittent fasting modulates SOD2, TFAM, Nrf2, and sirtuins (SIRT1, SIRT3) gene expressions in subjects with overweight and obesity.
Sign Up to like & getrecommendations! Published in 2019 at "Diabetes research and clinical practice"
DOI: 10.1016/j.diabres.2019.107801
Abstract: AIM A growing body of evidence supports the impact of intermittent fasting on normalizing body metabolism and lowering oxidative stress and inflammation. Mounting evidence confirms that oxidative stress and chronic inflammation trigger the way for… read more here.
Keywords: gene expressions; sod2 tfam; sirt1 sirt3; intermittent fasting ... See more keywords
Aucubin alleviates diabetic nephropathy by inhibiting NF-κB activation and inducing SIRT1/SIRT3-FOXO3a signaling pathway in high-fat diet/streptozotocin-induced diabetic mice
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Functional Foods"
DOI: 10.1016/j.jff.2019.103702
Abstract: Abstract Oxidative stress and inflammation are two important pathological mechanisms in diabetic nephropathy (DN). Aucubin (AU), a natural iridoid glucoside, possessing remarkable anti-inflammatory and anti-oxidation activity, has been used to treat diabetic complications. However, underlying… read more here.
Keywords: aucubin alleviates; signaling pathway; sirt1 sirt3; diabetic nephropathy ... See more keywords
Peripheral Maintenance of the Axis SIRT1-SIRT3 at Youth Level May Contribute to Brain Resilience in Middle-Aged Amateur Rugby Players
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Aging Neuroscience"
DOI: 10.3389/fnagi.2019.00352
Abstract: Physical exercise performed regularly is known to improve health and to reduce the risk of age-related diseases. Furthermore, there is some evidence of cognitive improvement in physically active middle-aged and older adults. We hypothesized that… read more here.
Keywords: rugby players; resilience; sirt1 sirt3; middle aged ... See more keywords