Isoorientin Attenuates Cisplatin-Induced Nephrotoxicity Through the Inhibition of Oxidative Stress and Apoptosis via Activating the SIRT1/SIRT6/Nrf-2 Pathway
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DOI: 10.3389/fphar.2020.00264
Abstract: Cisplatin (CDDP) is a widely used chemotherapeutic agent for various solid tumors, but its severe side effects, particularly nephrotoxicity, limit its clinical application. Isoorientin (Iso) is a flavonoid-like compound known to have antioxidant effects. As… read more here.
Keywords: oxidative stress; cddp induced; sirt1 sirt6; induced nephrotoxicity ... See more keywords
Hypothalamic Actions of SIRT1 and SIRT6 on Energy Balance
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DOI: 10.3390/ijms22031430
Abstract: Sirtuins are NAD+ dependent deacetylases that regulate a large number of physiological processes. These enzymes are highly conserved and act as energy sensors to coordinate different metabolic responses in a controlled manner. At present, seven… read more here.
Keywords: hypothalamic actions; energy; actions sirt1; energy balance ... See more keywords