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Published in 2020 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2020.00264
Abstract: Cisplatin (CDDP) is a widely used chemotherapeutic agent for various solid tumors, but its severe side effects, particularly nephrotoxicity, limit its clinical application. Isoorientin (Iso) is a flavonoid-like compound known to have antioxidant effects. As…
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Keywords:
oxidative stress;
cddp induced;
sirt1 sirt6;
induced nephrotoxicity ... See more keywords
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Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms22031430
Abstract: Sirtuins are NAD+ dependent deacetylases that regulate a large number of physiological processes. These enzymes are highly conserved and act as energy sensors to coordinate different metabolic responses in a controlled manner. At present, seven…
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Keywords:
hypothalamic actions;
energy;
actions sirt1;
energy balance ... See more keywords