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Published in 2018 at "ChemMedChem"
DOI: 10.1002/cmdc.201800391
Abstract: Sirtuin inhibitors have attracted much interest due to the involvement of sirtuins in various biological processes. Several SIRT2‐selective inhibitors have been developed, and some exhibit anticancer activities. To facilitate the choice of inhibitors in future…
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Keywords:
anticancer activities;
sirt2;
inhibition;
direct comparison ... See more keywords
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Published in 2021 at "ChemMedChem"
DOI: 10.1002/cmdc.202100343
Abstract: Small molecule inhibitors of SIRT2 are being developed because of their therapeutic potential in a variety of diseases. Here, we developed a high-throughput screen to identify novel SIRT2 inhibitors using a fluorescent SIRT2 probe, 1-aminoanthracene…
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Keywords:
defatty acylase;
ascorbyl palmitate;
deacetylase defatty;
sirt2 ... See more keywords
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Published in 2020 at "International Journal of Cancer"
DOI: 10.1002/ijc.33118
Abstract: Sirtuin 2 (SIRT2) belongs to the sirtuins family. It exists in many tissues and organs of the human body and regulates a wide range of biological functions. Studies have found that the abnormal expression of…
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Keywords:
sirt2;
role sirt2;
cancer novel;
sirt2 cancer ... See more keywords
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Published in 2017 at "Cellular and Molecular Neurobiology"
DOI: 10.1007/s10571-017-0537-6
Abstract: Sirtuin2 (SIRT2) is a deacetylase enzyme predominantly expressed in myelinating glia of the central nervous system (CNS). We have previously demonstrated that Sirt2 expression enhances oligodendrocyte (OL) differentiation and arborization in vitro, but the molecular…
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Keywords:
sirt2;
cholesterol;
cholesterol biosynthesis;
expression ... See more keywords
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Published in 2018 at "Inflammation"
DOI: 10.1007/s10753-018-0881-9
Abstract: Obesity increases morbidity and mortality in acute illnesses such as sepsis and septic shock. We showed previously that the early/hyper-inflammatory phase of sepsis is exaggerated in obese mice with sepsis; sirtuin 2 (SIRT2) modulates sepsis…
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Keywords:
sepsis;
oxidation;
sirt2;
inflammation ... See more keywords
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Published in 2020 at "Journal of Molecular Neuroscience"
DOI: 10.1007/s12031-020-01513-y
Abstract: The purpose of this study is to investigate the correlation between single-nucleotide polymorphism (SNP) at the 3' end of the untranslated region (UTR) of Sirtuin 2 ( SIRT2 ) gene and the risk of developing…
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Keywords:
sirt2;
rs2241703;
sirt2 gene;
expression ... See more keywords
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Published in 2019 at "Ageing Research Reviews"
DOI: 10.1016/j.arr.2019.100961
Abstract: Sirtuin 2 (SIRT2) is an NAD+-dependent deacetylase that was under studied compared to other sirtuin family members. SIRT2 is the only sirtuin protein which is predominantly found in the cytoplasm but is also found in…
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Keywords:
sirt2;
disease;
physiology;
role ... See more keywords
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Published in 2019 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2019.103281
Abstract: Sirtuins (SIRTs), class III HDAC (Histone deacetylase) family proteins, are associated with cancer, diabetes, and other age-related disorders. SIRT1 and SIRT2 are established therapeutic drug targets by regulating its function either by activators or inhibitors.…
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Keywords:
sirt1 sirt2;
design synthesis;
sirt2;
inhibitors sirt1 ... See more keywords
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Published in 2021 at "Cell reports"
DOI: 10.1016/j.celrep.2021.108921
Abstract: SUMMARY The breast cancer type I susceptibility protein (BRCA1) and BRCA1-associated RING domain protein I (BARD1) heterodimer promote genome integrity through pleiotropic functions, including DNA double-strand break (DSB) repair by homologous recombination (HR). BRCA1-BARD1 heterodimerization…
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Keywords:
bard1 heterodimerization;
brca1 bard1;
sirt2;
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Published in 2018 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2018.08.009
Abstract: Abstract Previous studies have shown that SIRT2 plays a role in mitosis through deacetylating specific downstream targets. However, the upstream regulation of SIRT2 activity has been relatively unexplored. In this study, we provide evidence that…
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Keywords:
sirt2 activity;
sirt2;
mitotic stress;
regulates mitotic ... See more keywords
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Published in 2021 at "Life sciences"
DOI: 10.1016/j.lfs.2021.119997
Abstract: AIM Sirtuin 2 (SIRT2) is a NAD+-dependent deacetylase involved in various biological functions via deacetylation of proteins, including histone protein. Hepatic fat accumulation from aging and excess caloric intake contribute to development of non-alcoholic fatty…
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Keywords:
accumulation;
sirt2;
liver;
sirtuin ... See more keywords