SIRT3 alleviates imiquimod-induced psoriatic dermatitis through deacetylation of XBP1s and modulation of TLR7/8 inducing IL-23 production in macrophages
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DOI: 10.3389/fimmu.2023.1128543
Abstract: Current evidence suggests that IL-23, IL-6, and TNF-α play pivotal roles in the pathogenesis of psoriasis. Although it has been established that Sirtuin 3 (SIRT3) mediates the inflammatory process, the underlying mechanisms remain largely unclear.… read more here.
Keywords: sirt3 alleviates; sirt3; production; imiquimod induced ... See more keywords