Asperosaponin VI mitigates mitochondrial dysfunction and chondrocyte apoptosis in osteoarthritis by modulating the AMPK-SIRT3 pathway
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DOI: 10.1007/s10565-025-10071-1
Abstract: To investigate the therapeutic potential of Asperosaponin VI (ASA VI) from Clematis chinensis in mitigating osteoarthritis (OA) progression by modulating the AMPK-SIRT3 pathway, specifically addressing ER stress, mitochondrial dysfunction, and chondrocyte apoptosis. In vitro studies… read more here.
Keywords: mitochondrial dysfunction; sirt3 pathway; ampk sirt3; chondrocyte apoptosis ... See more keywords
Honokiol Inhibits Atrial Metabolic Remodeling in Atrial Fibrillation Through Sirt3 Pathway
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DOI: 10.3389/fphar.2022.813272
Abstract: Background and Purpose: Atrial metabolic remodeling plays a critical role in the pathogenesis of atrial fibrillation (AF). Sirtuin3 (Sirt3) plays an important role in energy homeostasis. However, the effect of Sirt3 agonist Honokiol (HL) on… read more here.
Keywords: sirt3 pathway; atrial metabolic; atrial fibrillation; metabolic remodeling ... See more keywords
Type 2 Diabetes Induces a Pro-Oxidative Environment in Rat Epididymis by Disrupting SIRT1/PGC-1α/SIRT3 Pathway
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DOI: 10.3390/ijms23168912
Abstract: Diabetes mellitus type 2 (T2DM) has been associated with alterations in the male reproductive tract, especially in the epididymis. Although it is known that T2DM alters epididymal physiology, disturbing mitochondrial function and favoring oxidative stress,… read more here.
Keywords: pgc sirt3; sirt1 pgc; sirt3 pathway; t2dm ... See more keywords