Sestrin2 Regulates Mitochondrial Function and Autophagy via Nrf2/SIRT3 Signaling to Ameliorate Hypoxia/Reoxygenation‐Induced Rat's Cardiomyocyte Injury
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DOI: 10.1002/ddr.70150
Abstract: Mitigating myocardial ischemia‐reperfusion (I/R) injury poses a significant challenge, necessitating the exploration of novel therapeutic targets. Sestrin2 (Sesn2), a stress‐induced protein, has emerged as a potential candidate for attenuating I/R injury, yet its precise mechanisms… read more here.
Keywords: mitochondrial function; sirt3 signaling; nrf2 sirt3; injury ... See more keywords
Dihydromyricetin Protects Against Gentamicin-Induced Ototoxicity via PGC-1α/SIRT3 Signaling in vitro
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DOI: 10.3389/fcell.2020.00702
Abstract: Aminoglycoside-induced ototoxicity can have a major impact on patients’ quality of life and social development problems. Oxidative stress affects normal physiologic functions and has been implicated in aminoglycoside-induced inner ear injury. Excessive accumulation of reactive… read more here.
Keywords: gentamicin induced; pgc sirt3; induced ototoxicity; ototoxicity ... See more keywords