The absence of SIRT3 and SIRT5 promotes the acetylation of lens proteins and improves the chaperone activity of &agr;‐crystallin in mouse lenses
Sign Up to like & getrecommendations! Published in 2019 at "Experimental Eye Research"
DOI: 10.1016/j.exer.2019.02.024
Abstract: Abstract Acetylation of lysine residues occurs in lens proteins. Previous studies have shown an improvement in the chaperone activity of &agr;A‐crystallin upon acetylation. Sirtuins are NAD+‐dependent enzymes that can deacylate proteins. The roles of sirtuins… read more here.
Keywords: agr crystallin; mouse lenses; acetylation; sirt3 sirt5 ... See more keywords
Potent and Specific Activators for Mitochondrial Sirtuins Sirt3 and Sirt5.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c01215
Abstract: Sirtuins are NAD+-dependent protein deacylases involved in metabolic regulation and aging-related diseases. Specific activators for seven human Sirtuin isoforms would be important chemical tools and potential therapeutic drugs. Activators have been described for Sirt1 and… read more here.
Keywords: sirt3 sirt5; mitochondrial sirtuins; activators mitochondrial; specific activators ... See more keywords