Hyperinsulinemia impairs the metabolic switch to ketone body utilization in proximal renal tubular epithelial cells under energy crisis via the inhibition of the SIRT3/SMCT1 pathway
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DOI: 10.3389/fendo.2022.960835
Abstract: Objective To investigate the effects and mechanism of hyperinsulinemia on the metabolic switch to β‐hydroxybutyrate (BHB) absorption and utilization under a starvation or hypoxic environment in proximal tubular epithelial cells. Methods A high-fat diet-induced hyperinsulinemia… read more here.
Keywords: metabolic switch; sirt3; sirt3 smct1; epithelial cells ... See more keywords