Amelioration of myocardial ischemia-reperfusion injury by SIRT4 involves mitochondrial protection and reduced apoptosis.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.05.113
Abstract: Apoptosis and mitochondria dysfunction are key contributors to myocardial ischemia-reperfusion (MI-R) injury. SIRT4, a mitochondrial-localized sirtuin, controls cellular energy metabolism and stress response, and is abundantly present in the heart, however, its role in MI-R… read more here.
Keywords: sirt4; injury sirt4; myocardial ischemia; ischemia reperfusion ... See more keywords
Tumor suppressive role of mitochondrial sirtuin 4 in induction of G2/M cell cycle arrest and apoptosis in hepatitis B virus-related hepatocellular carcinoma
Sign Up to like & getrecommendations! Published in 2021 at "Cell Death Discovery"
DOI: 10.1038/s41420-021-00470-8
Abstract: Hepatocellular carcinoma (HCC) is developed from uncontrolled cell growth after the malignant transformation of hepatocytes. The hepatitis B virus (HBV) X protein (HBx) has shown to induce cell cycle progression and hepatocarcinogenesis. A sub-fraction of… read more here.
Keywords: sirt4; hcc; cell cycle; expression ... See more keywords
SIRT4 accelerates Ang II-induced pathological cardiac hypertrophy by inhibiting manganese superoxide dismutase activity
Sign Up to like & getrecommendations! Published in 2017 at "European Heart Journal"
DOI: 10.1093/eurheartj/ehw138
Abstract: Aims Oxidative stress contributes to the development of cardiac hypertrophy and heart failure. One of the mitochondrial sirtuins, Sirt4, is highly expressed in the heart, but its function remains unknown. The aim of the present… read more here.
Keywords: sirt4; cardiac hypertrophy; hypertrophy; mice ... See more keywords
Anabolic SIRT4 Exerts Retrograde Control over TORC1 Signaling by Glutamine Sparing in the Mitochondria
Sign Up to like & getrecommendations! Published in 2019 at "Molecular and Cellular Biology"
DOI: 10.1128/mcb.00212-19
Abstract: Anabolic and catabolic signaling mediated via mTOR and AMPK (AMP-activated kinase) have to be intrinsically coupled to mitochondrial functions for maintaining homeostasis and mitigate cellular/organismal stress. Although glutamine is known to activate mTOR, whether and… read more here.
Keywords: sirt4; mtor; torc1 signaling; glutamine sparing ... See more keywords
Bioinformatic Analysis of the Effect of the Sirtuin Family on Differentiated Thyroid Carcinoma
Sign Up to like & getrecommendations! Published in 2022 at "BioMed Research International"
DOI: 10.1155/2022/5794118
Abstract: A growing body of experimental evidence suggests that sirtuins (SIRTs) are associated with tumorigenesis in differentiated thyroid cancer (DTC). Nevertheless, the involvement of SIRTs in the pathogenesis of DTC and their clinical value remain ill-defined… read more here.
Keywords: sirt3 sirt4; sirt4 sirt5; sirt2 sirt3; differentiated thyroid ... See more keywords
Downregulation of lncRNA MALAT1 Inhibits Angiotensin II-induced Hypertrophic Effects of Cardiomyocytes by Regulating SIRT4 via miR-93-5p.
Sign Up to like & getrecommendations! Published in 2022 at "International heart journal"
DOI: 10.1536/ihj.21-332
Abstract: Cardiac hypertrophy is a leading risk for heart failure and sudden death. Long non-coding RNAs (lncRNAs) have been implicated in a variety of human diseases, including cardiac hypertrophy. We aimed to investigate the potential role… read more here.
Keywords: sirt4; expression; cardiac hypertrophy; malat1 ... See more keywords
SIRT4 acts as a tumor suppressor in gastric cancer by inhibiting cell proliferation, migration, and invasion
Sign Up to like & getrecommendations! Published in 2018 at "OncoTargets and therapy"
DOI: 10.2147/ott.s156143
Abstract: Background Previous study has proven that SIRT4 is downregulated in gastric cancer (GC), but the role of SIRT4 has not been clearly understood. The aim of our work was to explore in detail the function… read more here.
Keywords: sirt4; gastric cancer; cell proliferation; cell ... See more keywords
Sirtuin-4 (SIRT4), a therapeutic target with oncogenic and tumor-suppressive activity in cancer
Sign Up to like & getrecommendations! Published in 2018 at "OncoTargets and therapy"
DOI: 10.2147/ott.s157724
Abstract: Several members of the sirtuin (SIRT) family, a highly conserved family of NAD+-dependent enzymes, have been shown to play a critical role in both promoting and/or suppressing tumorigenesis. In this study, recent progress in the… read more here.
Keywords: sirt4; activity cancer; suppressive activity; cancer ... See more keywords
Proteomic profiling reveals the potential mechanisms and regulatory targets of sirtuin 4 in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson’s mouse model
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2022.1035444
Abstract: Introduction Parkinson’s disease (PD), as a common neurodegenerative disease, currently has no effective therapeutic approaches to delay or stop its progression. There is an urgent need to further define its pathogenesis and develop new therapeutic… read more here.
Keywords: mptp induced; sirt4; model; parkinson ... See more keywords
SIRT4 Is Highly Expressed in Retinal Müller Glial Cells
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2022.840443
Abstract: Sirtuin 4 (SIRT4) is one of seven mammalian sirtuins that possesses ADP-ribosyltransferase, lipoamidase and deacylase activities and plays indispensable role in metabolic regulation. However, the role of SIRT4 in the retina is not clearly understood.… read more here.
Keywords: sirt4; sirt4 highly; expression; ller glial ... See more keywords
SIRT4 Expression Ameliorates the Detrimental Effect of Heat Stress via AMPK/mTOR Signaling Pathway in BMECs
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232113307
Abstract: Sirtuin 4 (SIRT4), a member of the SIRT family, has been reported to be a key factor involved in antioxidant defense in mitochondria. This study aimed to explore the potential molecular mechanism via which SIRT4… read more here.
Keywords: stress; signaling pathway; sirt4; ampk mtor ... See more keywords