Dysregulation of the Sirt5/IDH2 axis contributes to sunitinib resistance in human renal cancer cells
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DOI: 10.1002/2211-5463.13090
Abstract: Sunitinib (Sun), a tyrosine kinase inhibitor of vascular endothelial growth factor receptor, is the standard first‐line treatment against advanced clear cell renal cell carcinoma (RCC), but resistance to therapy is inevitable. Reactive oxygen species production… read more here.
Keywords: sirt5; dysregulation sirt5; sirt5 idh2; sun ... See more keywords
LINC01234 regulates microRNA-27b-5p to induce the migration, invasion and self-renewal of ovarian cancer stem cells through targeting SIRT5
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DOI: 10.1080/15384101.2022.2040282
Abstract: ABSTRACT LINC01234 has been suggested to correlate with the survival of ovarian cancer (OS), but its role in the properties of OC stem cells (OCSCs) has been rarely described. We aim to investigate the effect… read more here.
Keywords: self renewal; ovarian cancer; sirt5; linc01234 ... See more keywords
P5381Lack of sirtuin 5 aggravates myocardial ischemia reperfusion injury
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DOI: 10.1093/eurheartj/ehz746.0341
Abstract: Sirtuin 5 (SIRT5) is a mitochondrial NAD+-dependent protein deacylase which regulates the enzymatic activity of numerous mitochondrial proteins due to increased succinylation and malonylation, including enzymes of energy substrate oxidation and mitochondrial antioxidant enzymes. Since… read more here.
Keywords: sirt5 mice; sirt5; sirtuin; injury ... See more keywords
Sirtuin 5 Is Regulated by the SCFCyclin F Ubiquitin Ligase and Is Involved in Cell Cycle Control
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DOI: 10.1128/mcb.00269-20
Abstract: The ubiquitin-proteasome system is essential for cell cycle progression. Cyclin F is a cell cycle-regulated substrate adapter F-box protein for the Skp1, CUL1, and F-box protein (SCF) family of E3 ubiquitin ligases. ABSTRACT The ubiquitin-proteasome… read more here.
Keywords: cycle; box protein; sirt5; cyclin ... See more keywords
Sirtuin 5-Mediated Lysine Desuccinylation Protects Mitochondrial Metabolism Following Subarachnoid Hemorrhage in Mice
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DOI: 10.1161/strokeaha.121.034850
Abstract: Supplemental Digital Content is available in the text. Background and Purpose: Sirt5 (Sirtuin 5) desuccinylates multiple metabolic enzymes and plays an important role in maintaining energy homeostasis. The goal of this study was to determine… read more here.
Keywords: sah; sirt5; metabolism; synthase ... See more keywords
SIRT5 As a Therapeutic Target in Acute Myeloid Leukemia
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DOI: 10.1182/blood-2018-99-115468
Abstract: Acute myeloid leukemia (AML) is an aggressive hematopoietic neoplasm with five-year overall survival rates read more here.
Keywords: cell lines; sirt5; sirt5 dependent; mice ... See more keywords
Sirtuin 5 Regulates Proximal Tubule Fatty Acid Oxidation to Protect against AKI.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the American Society of Nephrology : JASN"
DOI: 10.1681/asn.2019020163
Abstract: BACKGROUND The primary site of damage during AKI, proximal tubular epithelial cells, are highly metabolically active, relying on fatty acids to meet their energy demands. These cells are rich in mitochondria and peroxisomes, the two… read more here.
Keywords: fatty acid; sirt5; aki; acid oxidation ... See more keywords
The Brain Protein Acylation System Responds to Seizures in the Rat Model of PTZ-Induced Epilepsy
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DOI: 10.3390/ijms232012302
Abstract: Abnormal energy expenditure during seizures and metabolic regulation through post-translational protein acylation suggest acylation as a therapeutic target in epilepsy. Our goal is to characterize an interplay between the brain acylation system components and their… read more here.
Keywords: acylation system; protein acylation; seizures rat; expression ... See more keywords
SIRT5 promotes non-small cell lung cancer progression by reducing FABP4 acetylation level.
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DOI: 10.4149/neo_2022_220107n28
Abstract: This study evaluates the role of SIRT5 in non-small cell lung cancer (NSCLC) progression and explores the underlying mechanism. The expression and correlation of SIRT5 and FABP4 in lung cancer were analyzed by the GEPIA… read more here.
Keywords: sirt5; sirt5 fabp4; lung cancer; cell ... See more keywords
Prognostic value of sirtuin family members and experimental verification identify SIRT5 as diagnostic biomarkers in clear cell renal cell carcinoma
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DOI: 10.7717/peerj.15154
Abstract: Background The sirtuins (SIRTs) family is a nicotinamide adenine dinucleotide (NAD+) family of dependent deacetylases, which includes SIRT1-7. This family is related to the development and progression of various tumors. However, a comprehensive analysis of… read more here.
Keywords: cell; family; family members; ccrcc ... See more keywords