SIRT6 Depletion Sensitizes Human Hepatoma Cells to Chemotherapeutics by Downregulating MDR1 Expression
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DOI: 10.3389/fphar.2018.00194
Abstract: Multidrug resistance (MDR) due to overexpression of MDR1 is a major obstacle that hinders the treatment of hepatocellular carcinoma (HCC). In this study, we explored the function and underlying molecular mechanism of SIRT6 in MDR… read more here.
Keywords: hcc; chemotherapeutic agents; hcc cells; mdr1 ... See more keywords