Decreased Enterobacteriaceae translocation due to gut microbiota remodeling mediates the alleviation of premature aging by a high‐fat diet
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DOI: 10.1111/acel.13760
Abstract: Aging‐associated microbial dysbiosis exacerbates various disorders and dysfunctions, and is a major contributor to morbidity and mortality in the elderly, but the underlying cause of this aging‐related syndrome is confusing. SIRT6 knockout (SIRT6 KO) mice… read more here.
Keywords: sirt6 mice; premature; high fat; premature aging ... See more keywords
Characterization of physiological defects in adult SIRT6-/- mice
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DOI: 10.1371/journal.pone.0176371
Abstract: The NAD+-dependent SIRT6 deacetylase was shown to be a major regulator of lifespan and healthspan. Mice deficient for SIRT6 develop a premature aging phenotype and metabolic defects, and die before four weeks of age. Thus,… read more here.
Keywords: age; sirt6 mice; adult mice; mice ... See more keywords