SIRT6 overexpression in the nucleus protects mouse retinal pigment epithelium from oxidative stress
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DOI: 10.26508/lsa.202201448
Abstract: Oxidative stress causes a rapid translocation of SIRT6 from the nucleus to the cytoplasm leading to nuclear SIRT6 depletion and results in RPE damage that is more severe in the central region in mice. read more here.
Keywords: stress; oxidative stress; nucleus protects; overexpression nucleus ... See more keywords
SIRT6 overexpression retards renal interstitial fibrosis through targeting HIPK2 in chronic kidney disease
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DOI: 10.3389/fphar.2022.1007168
Abstract: Introduction: Renal interstitial fibrosis is a common pathophysiological change in the chronic kidney disease (CKD). Nicotinamide adenine dinucleotide (NAD)-dependent deacetylase sirtuin 6 (SIRT6) is demonstrated to protect against kidney injury. Vitamin B3 is the mostly… read more here.
Keywords: hipk2; kidney; interstitial fibrosis; renal interstitial ... See more keywords