Abstract Th0051: SIRT6 Overexpression Fails to Protect Against Age-Associated Vascular Dysfunction in Mice
Sign Up to like & getrecommendations! Published in 2025 at "Arteriosclerosis, Thrombosis, and Vascular Biology"
DOI: 10.1161/atv.45.suppl_1.th0051
Abstract: Introduction: Previous findings suggest that sirtuin 6 (SIRT6), a nuclear histone deacetylase, is involved in fundamental processes that regulate aging, which include DNA damage repair and maintenance of genomic stability. It remains unclear, however, whether… read more here.
Keywords: age; mice; sirt6; sirt6 overexpression ... See more keywords
SIRT6 overexpression in the nucleus protects mouse retinal pigment epithelium from oxidative stress
Sign Up to like & getrecommendations! Published in 2023 at "Life Science Alliance"
DOI: 10.26508/lsa.202201448
Abstract: Oxidative stress causes a rapid translocation of SIRT6 from the nucleus to the cytoplasm leading to nuclear SIRT6 depletion and results in RPE damage that is more severe in the central region in mice. read more here.
Keywords: stress; oxidative stress; nucleus protects; overexpression nucleus ... See more keywords
SIRT6 overexpression retards renal interstitial fibrosis through targeting HIPK2 in chronic kidney disease
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.1007168
Abstract: Introduction: Renal interstitial fibrosis is a common pathophysiological change in the chronic kidney disease (CKD). Nicotinamide adenine dinucleotide (NAD)-dependent deacetylase sirtuin 6 (SIRT6) is demonstrated to protect against kidney injury. Vitamin B3 is the mostly… read more here.
Keywords: hipk2; kidney; interstitial fibrosis; renal interstitial ... See more keywords