Hyperglycemia affects global 5-methylcytosine and 5-hydroxymethylcytosine in blood genomic DNA through upregulation of SIRT6 and TETs
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DOI: 10.1186/s13148-019-0660-y
Abstract: BackgroundAccumulating evidence suggests that epigenetic changes play key roles in the pathogenesis of type 2 diabetes mellitus (T2DM). However, the dynamic regulation of 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) in diabetic peripheral blood DNA remains to… read more here.
Keywords: hydroxymethylcytosine; genomic dna; sirt6 tets; methylcytosine ... See more keywords