Quantitative proteome‐based systematic identification of SIRT7 substrates
Sign Up to like & getrecommendations! Published in 2017 at "PROTEOMICS"
DOI: 10.1002/pmic.201600395
Abstract: SIRT7 is a class III histone deacetylase that is involved in numerous cellular processes. Only six substrates of SIRT7 have been reported thus far, so we aimed to systematically identify SIRT7 substrates using stable‐isotope labeling… read more here.
Keywords: sirt7 substrates; acetylation; based systematic; quantitative proteome ... See more keywords
LncRNA, PLXDC2‐OT promoted the osteogenesis potentials of MSCs by inhibiting the deacetylation function of RBM6/SIRT7 complex and OSX specific isoform
Sign Up to like & getrecommendations! Published in 2021 at "STEM CELLS"
DOI: 10.1002/stem.3362
Abstract: Bone regeneration and remodeling are complex physiological processes that are regulated by key transcription factors. Understanding the regulatory mechanism of key transcription factors on the osteogenic differentiation of mesenchymal stem cells (MSCs) is a key… read more here.
Keywords: osx; sirt7; function; osteogenesis ... See more keywords
Sirtuin 7-dependent deacetylation of DDB1 regulates the expression of nuclear receptor TR4.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.06.057
Abstract: Sirtuin 7 (SIRT7) is an NAD+-dependent deacetylase/deacylase, but only a limited number of SIRT7 substrates have been identified. Recently, we found that Sirt7 knockout mice are resistant to high-fat diet-induced fatty liver, and that SIRT7… read more here.
Keywords: ddb1; deacetylation; tr4; nuclear receptor ... See more keywords
SIRT7 Is an RNA-Activated Protein Lysine Deacylase.
Sign Up to like & getrecommendations! Published in 2017 at "ACS chemical biology"
DOI: 10.1021/acschembio.6b00954
Abstract: Mammalian SIRT7 is a member of the sirtuin family that regulates multiple biological processes including genome stability, metabolic pathways, stress responses, and tumorigenesis. SIRT7 has been shown to be important for ribosome biogenesis and transcriptional… read more here.
Keywords: rna activated; rna; activated protein; sirt7 rna ... See more keywords
H2O2 down-regulates SIRT7’s protective role of endothelial premature dysfunction via microRNA-335-5p
Sign Up to like & getrecommendations! Published in 2022 at "Bioscience Reports"
DOI: 10.1042/bsr20211775
Abstract: Abstract Endothelial senescence is believed to constitute the initial pathogenesis of the atherosclerotic cardiovascular disease (ASCVD). MicroRNA-335-5p (miR-335-5p) expression is significantly up-regulated in oxidative stress-induced endothelial cells (ECs). Sirtuin7 (SIRT7) is considered to prevent EC… read more here.
Keywords: mir 335; microrna 335; sirt7; senescence ... See more keywords
Sirtuins and DNA damage repair: SIRT7 comes to play
Sign Up to like & getrecommendations! Published in 2017 at "Nucleus"
DOI: 10.1080/19491034.2016.1264552
Abstract: ABSTRACT Aging is characterized by a cumulative loss of genome integrity, which involves chromatin reorganization, transcriptional dysregulation and the accumulation of DNA damage. Sirtuins participate in the protection against these aging processes by promoting genome… read more here.
Keywords: dna damage; sirtuins dna; damage; sirt7 ... See more keywords
SIRT7 regulates lipogenesis in adipocytes through deacetylation of PPARγ2
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Diabetes Investigation"
DOI: 10.1111/jdi.13567
Abstract: Peroxisome proliferator‐activated receptor (PPAR)‐γ2 is a transcription factor crucial for regulating adipogenesis and glucose/lipid metabolism, and synthetic PPARγ ligands, such as thiazolidinediones, are effective oral medication for type 2 diabetes. Sirtuin 7 (SIRT7), a nicotinamide… read more here.
Keywords: sirt7 regulates; lipogenesis adipocytes; deacetylation ppar; sirt7 ... See more keywords
SIRT7 modulates the stability and activity of the renal K‐Cl cotransporter KCC4 through deacetylation
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DOI: 10.15252/embr.202050766
Abstract: SIRT7 is a NAD+‐dependent deacetylase that controls important aspects of metabolism, cancer, and bone formation. However, the molecular targets and functions of SIRT7 in the kidney are currently unknown. In silico analysis of kidney transcripts… read more here.
Keywords: stability activity; activity; cotransporter kcc4; sirt7 ... See more keywords
Long noncoding RNA and mRNA profiling in MDA-MB-231 cells following RNAi-mediated knockdown of SIRT7
Sign Up to like & getrecommendations! Published in 2017 at "OncoTargets and therapy"
DOI: 10.2147/ott.s149048
Abstract: Breast cancer is one of the most common malignant cancers among women and a major clinical obstacle. Although studies have reported the abnormal expression of SIRT7 in breast cancer, whether the function of SIRT7 regulates… read more here.
Keywords: breast cancer; sirt7; cancer; differentially expressed ... See more keywords
Sirtuin 7 Inhibitor Attenuates Colonic Mucosal Immune Activation in Mice—Potential Therapeutic Target in Inflammatory Bowel Disease
Sign Up to like & getrecommendations! Published in 2022 at "Biomedicines"
DOI: 10.3390/biomedicines10112693
Abstract: Accumulating evidence has shown that sirtuin 7 (SIRT7), a mediator of various cellular activities, plays an important role in the pathogenesis of various immune-mediated inflammatory disorders. However, information remains limited regarding the role of SIRT7… read more here.
Keywords: inflammation; sirt7; role; inhibitor ... See more keywords
Zebrafish sirt7 Negatively Regulates Antiviral Responses by Attenuating Phosphorylation of irf3 and irf7 Independent of Its Enzymatic Activity.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of immunology"
DOI: 10.4049/jimmunol.2100318
Abstract: Sirt7 is one member of the sirtuin family proteins with NAD (NAD+)-dependent histone deacetylase activity. In this study, we report that zebrafish sirt7 is induced upon viral infection, and overexpression of sirt7 suppresses cellular antiviral… read more here.
Keywords: zebrafish sirt7; activity; sirt7; phosphorylation irf3 ... See more keywords