In‐depth analysis of the Sirtuin 5‐regulated mouse brain malonylome and succinylome using library‐free data‐independent acquisitions
Sign Up to like & getrecommendations! Published in 2022 at "PROTEOMICS"
DOI: 10.1002/pmic.202100371
Abstract: Post‐translational modifications (PTMs) dynamically regulate proteins and biological pathways, typically through the combined effects of multiple PTMs. Lysine residues are targeted for various PTMs, including malonylation and succinylation. However, PTMs offer specific challenges to mass… read more here.
Keywords: data independent; free data; sirtuin; mouse brain ... See more keywords
Pinitol alleviates systemic inflammatory cytokines in human obesity by a mechanism involving unfolded protein response and sirtuin 1.
Sign Up to like & getrecommendations! Published in 2018 at "Clinical nutrition"
DOI: 10.1016/j.clnu.2017.09.015
Abstract: BACKGROUND & AIMS It is known that pinitol acts as a mediator of the insulin-signaling pathway, though little is known about its anti-inflammatory effect in human obesity. Therefore, this study aimed to evaluate the effect… read more here.
Keywords: protein; sirtuin; pinitol alleviates; human obesity ... See more keywords
The role of Sirtuin 2 in sustaining functional integrity of the liver.
Sign Up to like & getrecommendations! Published in 2021 at "Life sciences"
DOI: 10.1016/j.lfs.2021.119997
Abstract: AIM Sirtuin 2 (SIRT2) is a NAD+-dependent deacetylase involved in various biological functions via deacetylation of proteins, including histone protein. Hepatic fat accumulation from aging and excess caloric intake contribute to development of non-alcoholic fatty… read more here.
Keywords: accumulation; sirt2; liver; sirtuin ... See more keywords
Structural Basis of Sirtuin 6-Catalyzed Nucleosome Deacetylation.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c13512
Abstract: The reversible acetylation of histone lysine residues is controlled by the action of acetyltransferases and deacetylases (HDACs), which regulate chromatin structure and gene expression. The sirtuins are a family of NAD-dependent HDAC enzymes, and one… read more here.
Keywords: deacetylation; histone; sirt6; structural basis ... See more keywords
Ainsliadimer C, a disesquiterpenoid isolated from Ainsliaea macrocephala, ameliorates inflammatory responses in adipose tissue via Sirtuin 1-NLRP3 inflammasome axis.
Sign Up to like & getrecommendations! Published in 2021 at "Acta pharmacologica Sinica"
DOI: 10.1038/s41401-021-00797-z
Abstract: Interleukin-1β (IL-1β), a key pro-inflammatory cytokine, is majorly produced by macrophages through NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasome, which has been identified as the culprit to deteriorate the inflammatory crosstalk between macrophages… read more here.
Keywords: tissue; sirtuin; disesquiterpenoid isolated; adipose tissue ... See more keywords
Structural basis for the activation and inhibition of Sirtuin 6 by quercetin and its derivatives
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-55654-1
Abstract: Mammalian Sirtuin 6 (Sirt6) is an NAD+-dependent protein deacylase regulating metabolism and chromatin homeostasis. Sirt6 activation protects against metabolic and aging-related diseases, and Sirt6 inhibition is considered a cancer therapy. Available Sirt6 modulators show insufficient… read more here.
Keywords: structural basis; sirtuin; site; quercetin ... See more keywords
P5381Lack of sirtuin 5 aggravates myocardial ischemia reperfusion injury
Sign Up to like & getrecommendations! Published in 2019 at "European Heart Journal"
DOI: 10.1093/eurheartj/ehz746.0341
Abstract: Sirtuin 5 (SIRT5) is a mitochondrial NAD+-dependent protein deacylase which regulates the enzymatic activity of numerous mitochondrial proteins due to increased succinylation and malonylation, including enzymes of energy substrate oxidation and mitochondrial antioxidant enzymes. Since… read more here.
Keywords: sirt5 mice; sirt5; sirtuin; injury ... See more keywords
Sirtuin 6 promotes eosinophil differentiation by activating GATA‐1 transcription factor
Sign Up to like & getrecommendations! Published in 2021 at "Aging Cell"
DOI: 10.1111/acel.13418
Abstract: There is evidence emerging that exposure to cold temperatures enhances alternative activation of macrophages in white adipose tissue (WAT), which promotes adipocyte beiging and adaptive thermogenesis. Although we recently reported that NAD+‐dependent deacetylase sirtuin 6… read more here.
Keywords: sirtuin; myeloid sirt6; sirt6; eosinophil differentiation ... See more keywords
Sirtuin 1 alleviates neuroinflammation‐induced apoptosis after traumatic brain injury
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.16534
Abstract: Sirtuin 1 (SIRT1) plays a very important role in a wide range of biological responses, such as metabolism, inflammation and cell apoptosis. Changes in the levels of SIRT1 have been detected in the brain after… read more here.
Keywords: sirt1; traumatic brain; apoptosis; sirtuin ... See more keywords
The regulatory role of Sirtuin 6 in coronary endothelial dysfunction in HFpEF
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DOI: 10.1152/physiol.2023.38.s1.5733428
Abstract: Sirtuin 6 (Sirt6) has been implicated in obesity, insulin resistance, type 2 diabetes mellitus, and cardiovascular diseases. Sirt6 protects EC from premature senescence, oxidative stress, and atherosclerosis by sustaining high eNOS levels and preserving cell… read more here.
Keywords: function; hfpef; sirt6; physiology ... See more keywords
Effect of Sirtuin-1 and Wnt/β-Catenin Signaling Pathway in Rat Model of Spinal Cord Injury
Sign Up to like & getrecommendations! Published in 2022 at "Computational and Mathematical Methods in Medicine"
DOI: 10.1155/2022/1799607
Abstract: Sirtuin-1 (SIRT1) has anti-inflammatory and antioxidant effects and has been reported to be involved in spinal cord injury (SCI). Wnt/β-catenin signal has been shown to play a critical role in the pathogenesis of chronic diseases,… read more here.
Keywords: cord injury; wnt catenin; sirtuin; rat model ... See more keywords