In‐depth analysis of the Sirtuin 5‐regulated mouse brain malonylome and succinylome using library‐free data‐independent acquisitions
Sign Up to like & getrecommendations! Published in 2022 at "PROTEOMICS"
DOI: 10.1002/pmic.202100371
Abstract: Post‐translational modifications (PTMs) dynamically regulate proteins and biological pathways, typically through the combined effects of multiple PTMs. Lysine residues are targeted for various PTMs, including malonylation and succinylation. However, PTMs offer specific challenges to mass… read more here.
Keywords: data independent; free data; sirtuin; mouse brain ... See more keywords
Exploring the therapeutic potential of quercetin: A focus on its sirtuin‐mediated benefits
Sign Up to like & getrecommendations! Published in 2024 at "Phytotherapy Research"
DOI: 10.1002/ptr.8168
Abstract: As the global population ages, preventing lifestyle‐ and aging‐related diseases is increasing, necessitating the search for safe and affordable therapeutic interventions. Among nutraceuticals, quercetin, a flavonoid ubiquitously present in various plants, has garnered considerable interest.… read more here.
Keywords: sirtuin; focus; quercetin; therapeutic potential ... See more keywords
Pinitol alleviates systemic inflammatory cytokines in human obesity by a mechanism involving unfolded protein response and sirtuin 1.
Sign Up to like & getrecommendations! Published in 2018 at "Clinical nutrition"
DOI: 10.1016/j.clnu.2017.09.015
Abstract: BACKGROUND & AIMS It is known that pinitol acts as a mediator of the insulin-signaling pathway, though little is known about its anti-inflammatory effect in human obesity. Therefore, this study aimed to evaluate the effect… read more here.
Keywords: protein; sirtuin; pinitol alleviates; human obesity ... See more keywords
The role of Sirtuin 2 in sustaining functional integrity of the liver.
Sign Up to like & getrecommendations! Published in 2021 at "Life sciences"
DOI: 10.1016/j.lfs.2021.119997
Abstract: AIM Sirtuin 2 (SIRT2) is a NAD+-dependent deacetylase involved in various biological functions via deacetylation of proteins, including histone protein. Hepatic fat accumulation from aging and excess caloric intake contribute to development of non-alcoholic fatty… read more here.
Keywords: accumulation; sirt2; liver; sirtuin ... See more keywords
Structural Basis of Sirtuin 6-Catalyzed Nucleosome Deacetylation.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c13512
Abstract: The reversible acetylation of histone lysine residues is controlled by the action of acetyltransferases and deacetylases (HDACs), which regulate chromatin structure and gene expression. The sirtuins are a family of NAD-dependent HDAC enzymes, and one… read more here.
Keywords: deacetylation; histone; sirt6; structural basis ... See more keywords
Ainsliadimer C, a disesquiterpenoid isolated from Ainsliaea macrocephala, ameliorates inflammatory responses in adipose tissue via Sirtuin 1-NLRP3 inflammasome axis.
Sign Up to like & getrecommendations! Published in 2021 at "Acta pharmacologica Sinica"
DOI: 10.1038/s41401-021-00797-z
Abstract: Interleukin-1β (IL-1β), a key pro-inflammatory cytokine, is majorly produced by macrophages through NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasome, which has been identified as the culprit to deteriorate the inflammatory crosstalk between macrophages… read more here.
Keywords: tissue; sirtuin; disesquiterpenoid isolated; adipose tissue ... See more keywords
Structural basis for the activation and inhibition of Sirtuin 6 by quercetin and its derivatives
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-55654-1
Abstract: Mammalian Sirtuin 6 (Sirt6) is an NAD+-dependent protein deacylase regulating metabolism and chromatin homeostasis. Sirt6 activation protects against metabolic and aging-related diseases, and Sirt6 inhibition is considered a cancer therapy. Available Sirt6 modulators show insufficient… read more here.
Keywords: structural basis; sirtuin; site; quercetin ... See more keywords
Sirtuin modulators: a review of patents from 2020 to 2024.
Sign Up to like & getrecommendations! Published in 2025 at "Expert opinion on therapeutic patents"
DOI: 10.1080/13543776.2025.2585821
Abstract: ABSTRACT Introduction Sirtuins have gained significant prominence in scientific research due to their involvement in a wide array of biological processes, including DNA repair, genome stability, transcription modulation, and signal transduction. Dysregulation of their function… read more here.
Keywords: sirtuin; patents 2020; modulators review; 2020 2024 ... See more keywords
P5381Lack of sirtuin 5 aggravates myocardial ischemia reperfusion injury
Sign Up to like & getrecommendations! Published in 2019 at "European Heart Journal"
DOI: 10.1093/eurheartj/ehz746.0341
Abstract: Sirtuin 5 (SIRT5) is a mitochondrial NAD+-dependent protein deacylase which regulates the enzymatic activity of numerous mitochondrial proteins due to increased succinylation and malonylation, including enzymes of energy substrate oxidation and mitochondrial antioxidant enzymes. Since… read more here.
Keywords: sirt5 mice; sirt5; sirtuin; injury ... See more keywords
Sirtuin 6 promotes eosinophil differentiation by activating GATA‐1 transcription factor
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DOI: 10.1111/acel.13418
Abstract: There is evidence emerging that exposure to cold temperatures enhances alternative activation of macrophages in white adipose tissue (WAT), which promotes adipocyte beiging and adaptive thermogenesis. Although we recently reported that NAD+‐dependent deacetylase sirtuin 6… read more here.
Keywords: sirtuin; myeloid sirt6; sirt6; eosinophil differentiation ... See more keywords
Ginsenoside Rh1 mitigates mitochondrial dysfunction induced by myocardial ischaemia through its novel role as a sirtuin 3 activator
Sign Up to like & getrecommendations! Published in 2025 at "British Journal of Pharmacology"
DOI: 10.1111/bph.70022
Abstract: The sirtuin 3 (SIRT3) signalling pathway is an essential target for various cardiovascular diseases (CVDs), although effective interventions in myocardial ischaemia‐induced mitochondrial dysfunction remain to be elucidated. Here, we discovered a potent SIRT3 activator and… read more here.
Keywords: sirtuin; mitochondrial dysfunction; myocardial ischaemia; dysfunction ... See more keywords