Synergistic Silencing of Skp2 by siRNA Self-Assembled Nanoparticles as a Therapeutic Strategy for Advanced Prostate Cancer.
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DOI: 10.1002/smll.202106046
Abstract: Advanced prostate cancer, harboring multiple mutations of tumor suppressor genes, is refractory to conventional therapies. Knockout of the Skp2 gene blocks pRb/p53 doubly deficient prostate cancer in mice, which inspired the authors to develop an… read more here.
Keywords: prostate cancer; siskp2 que; strategy; advanced prostate ... See more keywords