Compaction and Segregation of Sister Chromatids by Loop-Extruding Enzymes
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DOI: 10.1016/j.bpj.2016.11.2024
Abstract: During cell division, two copies of each chromosome are segregated from each other and compacted more than hundred-fold into the canonical X-shaped structures. According to earlier microscopic observations and the recent Hi-C study, mitotic chromosomes… read more here.
Keywords: sister chromatids; loop extruding; segregation sister; compaction segregation ... See more keywords
Cohesin and chromosome segregation
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DOI: 10.1016/j.cub.2018.05.019
Abstract: Summary Cohesin is a ring-shaped protein complex that organises the genome, enabling its condensation, expression, repair and transmission. Cohesin is best known for its role in chromosome segregation, where it provides the cohesion that is… read more here.
Keywords: cohesin; sister chromatids; chromosome segregation; segregation ... See more keywords
Mitotic drive in asymmetric epigenetic inheritance
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DOI: 10.1042/bst20200267
Abstract: Asymmetric cell division (ACD) produces two daughter cells with distinct cell fates. This division mode is widely used during development and by adult stem cells during tissue homeostasis and regeneration, which can be regulated by… read more here.
Keywords: cell; epigenetic inheritance; sister chromatids; mitotic drive ... See more keywords
Sister chromatids separate during anaphase in a three-stage program as directed by interaxis bridges
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2123363119
Abstract: Significance A central feature of mitosis is segregation of sister chromatids to opposite poles during anaphase. Our recent work revealed that sister chromatids are linked by robust structural bridges built on topological sister/sister catenations. This… read more here.
Keywords: sister chromatids; chromatids separate; anaphase; three stage ... See more keywords
Separase and Roads to Disengage Sister Chromatids during Anaphase
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DOI: 10.3390/ijms24054604
Abstract: Receiving complete and undamaged genetic information is vital for the survival of daughter cells after chromosome segregation. The most critical steps in this process are accurate DNA replication during S phase and a faithful chromosome… read more here.
Keywords: spindle apparatus; chromosome segregation; anaphase; sister chromatids ... See more keywords