Study of the interaction of broad‐spectrum antimicrobial drug sitafloxacin with human serum albumin using spectroscopic methods, molecular docking, and molecular dynamics simulation
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Pharmaceutical and Biomedical Analysis"
DOI: 10.1016/j.jpba.2018.07.053
Abstract: HIGHLIGHTSThe interaction between sitafloxacin and human serum albumin has been firstly investigated.Quenching mechanism, binding constants, thermodynamic parameters, and binding modes were discussed and mutually confirmed.Molecular dynamics simulations were performed to further analyze the HSA‐sitafloxacin complex… read more here.
Keywords: sitafloxacin human; molecular dynamics; human serum; interaction ... See more keywords
A randomized, active-controlled, multicentre clinical trial to evaluate the efficacy and safety of oral sitafloxacin versus levofloxacin in Chinese adults with acute uncomplicated or complicated urinary tract infection
Sign Up to like & getrecommendations! Published in 2021 at "Annals of Medicine"
DOI: 10.1080/07853890.2020.1861322
Abstract: Abstract Purpose To evaluate the efficacy and safety of oral sitafloxacin versus levofloxacin in Chinese adults with acute uncomplicated urinary tract infection (UTI) or complicated UTI. Methods In this randomized, active-controlled clinical trial, the patients… read more here.
Keywords: urinary tract; oral sitafloxacin; rate; chinese adults ... See more keywords
Acquisition of double mutation in gyrA caused high resistance to sitafloxacin in Helicobacter pylori after unsuccessful eradication with sitafloxacin-containing regimens
Sign Up to like & getrecommendations! Published in 2018 at "United European Gastroenterology Journal"
DOI: 10.1177/2050640617737215
Abstract: Background and aim Although sitafloxacin (STFX)-containing regimens are effective rescue treatments for Helicobacter pylori infection, prevalence of fluoroquinolone resistance in H. pylori has increased rapidly worldwide. The change in resistance levels and gyrA mutations, a… read more here.
Keywords: eradication; containing regimens; pylori unsuccessful; stfx containing ... See more keywords
Sitafloxacin Expresses Potent Anti-Mycobacterium abscessus Activity
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2021.779531
Abstract: Therapeutic options for treating Mycobacterium abscessus infections are extremely limited; quinolones are important. The in vitro anti-M. abscessus activities of nine quinolones, emphasizing sitafloxacin, were investigated. Antimicrobial susceptibility testing was performed on 10 non-tuberculous mycobacterium… read more here.
Keywords: mycobacterium abscessus; abscessus activity; sitafloxacin; abscessus ... See more keywords