Sitagliptin promotes mitochondrial biogenesis in human SH‐SY5Y cells by increasing the expression of PGC‐1α/NRF1/TFAM
Sign Up to like & getrecommendations! Published in 2019 at "IUBMB Life"
DOI: 10.1002/iub.2076
Abstract: Mitochondrial dysfunction has been associated with the pathogenesis of a variety of neurodegenerative diseases. Sitagliptin is a dipeptidyl‐peptidase‐4 (DPP‐4) inhibitor that has been approved for the treatment of type 2 diabetes (T2DM). In the current… read more here.
Keywords: nrf1 tfam; sitagliptin; pgc nrf1; expression ... See more keywords
Neuroprotective influence of sitagliptin against cisplatin-induced neurotoxicity, biochemical and behavioral alterations in Wistar rats
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DOI: 10.1007/s11010-018-3472-z
Abstract: Cisplatin has been extensively used as a chemotherapeutic agent since around 40 years, though its usage is limited due to severe adverse effects like neurotoxicity that might be because of oxidative stress. Hence, the present… read more here.
Keywords: biochemical behavioral; sitagliptin; cisplatin; group ... See more keywords
Determination of chemical stability of sitagliptin by LC‐UV, LC‐MS and FT‐IR methods
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Pharmaceutical and Biomedical Analysis"
DOI: 10.1016/j.jpba.2018.11.023
Abstract: Graphical abstract Figure. No Caption available. HighlightsComprehensive evaluation of chemical stability of sitagliptin was performed.Kinetics of degradation was examined for the first time.Stability of the drug in the presence of excipients was checked for the… read more here.
Keywords: degradation; presence; sitagliptin; chemical stability ... See more keywords
Beneficial effect of sitagliptin on high fat diet induced obesity in wistar rats
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DOI: 10.1016/j.obmed.2019.100084
Abstract: Abstract Purpose Obesity is one of the rising health problems and has become a major concern with highest prevalent global epidemiology. Various evidences suggest that the action or effect of glucagon-like-peptide-1 (GLP-1), which acts as… read more here.
Keywords: beneficial effect; sitagliptin; high fat; obesity ... See more keywords
Dipeptidyl peptidase 4 inhibitor sitagliptin protected against dextran sulfate sodium-induced experimental colitis by potentiating the action of GLP-2
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DOI: 10.1038/s41401-020-0413-7
Abstract: Dipeptidyl peptidase 4 (DPP4), a ubiquitously expressed protease that cleaves off the N-terminal dipeptide from proline and alanine on the penultimate position, has important roles in many physiological processes. In the present study, experimental colitis… read more here.
Keywords: sitagliptin; dss induced; glp; colitis ... See more keywords
Dipeptidyl Peptidase-4 Inhibitor Sitagliptin Exhibits Antioxidant Mechanism for Abrogation of Cyclophosphamide-Induced Cardiac Damage and Oxidative Hepatorenal Toxicity in Rats.
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DOI: 10.1055/a-1842-7596
Abstract: Cyclophosphamide (CYP) is a potent DNA-interactive anticancer drug; however, its clinical drawbacks are chiefly associated with induction of oxidative multi-organ toxicity. Sitagliptin (STG) is an antidiabetic dipeptidyl peptidase-4 inhibitor drug with antioxidant efficacy. Herein, we… read more here.
Keywords: dipeptidyl peptidase; sitagliptin; peptidase inhibitor; toxicity ... See more keywords
Sitagliptin ameliorates hypoxia-induced damages in endometrial stromal cells: an implication in endometriosis
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DOI: 10.1080/21655979.2021.2012950
Abstract: ABSTRACT Hypoxia-induced damage in endometrial stromal cells (ESCs) is an important event in the pathological progression of Endometriosis. It is reported that significant inflammation is induced by hypoxia in ESCs, mediated by serval inflammatory progressions,… read more here.
Keywords: hypoxia induced; sitagliptin; endometrial stromal; induced damages ... See more keywords
Sitagliptin mitigates hypoxia/reoxygenation (H/R)-induced injury in cardiomyocytes by mediating sirtuin 3 (SIRT3) and autophagy
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DOI: 10.1080/21655979.2022.2074109
Abstract: ABSTRACT Potential ischemia/reperfusion (I/R) injuries are commonly induced during treatment of cardiovascular diseases, such as acute myocardial infarction (AMI). It is reported that oxidative stress and over-autophagy in cardiomyocytes are involved in the pathogenesis of… read more here.
Keywords: sitagliptin; hypoxia reoxygenation; sirt3; injury ... See more keywords
388: LIFE-THREATENING ANGIOEDEMA ASSOCIATED WITH ACEI AND SITAGLIPTIN COMBINATION THERAPY
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DOI: 10.1097/01.ccm.0000528407.24078.64
Abstract: Critical Care Medicine • Volume 46 • Number 1 (Supplement) www.ccmjournal.org Learning Objectives: While the link between bradykinin induced angioedema and angiotensinconverting enzyme inhibitors (ACEI) is well established, less data exists on angioedema resulting from… read more here.
Keywords: medicine; sitagliptin; life threatening; dpp ... See more keywords
Sitagliptin Versus Placebo to Reduce the Incidence and Severity of Posttransplant Diabetes Mellitus After Kidney Transplantation—A Single-center, Randomized, Double-blind Controlled Trial
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DOI: 10.1097/tp.0000000000004373
Abstract: Background. Postkidney transplant diabetes mellitus (PTDM) affects cardiovascular, allograft, and recipient health. We tested whether early intervention with sitagliptin for hyperglycemia (blood glucose >200 mg/dL) within the first week of transplant and discontinued at 3… read more here.
Keywords: sitagliptin; arm; posttransplant; placebo ... See more keywords
Sitagliptin protects male albino rats with testicular ischaemia/reperfusion damage: Modulation of VCAM‐1 and VEGF‐A
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DOI: 10.1111/and.13472
Abstract: Twisting of the spermatic cord is considered a popular problem in the urological field, which may lead to testicular necrosis and male infertility. Sitagliptin, a glucose‐lowering agent, proved to have a vindicatory function in myocardial… read more here.
Keywords: sitagliptin; protects male; sitagliptin protects; ischaemia reperfusion ... See more keywords