Comprehensive Synthesis of Amino Acid-Derived Thiazole Peptidomimetic Analogues to Understand the Enigmatic Drug/Substrate-Binding Site of P-Glycoprotein.
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DOI: 10.1021/acs.jmedchem.7b01340
Abstract: A novel set of 64 analogues based on our lead compound 1 was designed and synthesized with an initial objective of understanding the structural requirements of ligands binding to a highly perplexing substrate-binding site of… read more here.
Keywords: comprehensive synthesis; binding site; substrate binding; site glycoprotein ... See more keywords