Molecular modelling of two coordination states of Zn(II) ion at the active site of human carbonic anhydrase II
Sign Up to like & getrecommendations! Published in 2021 at "Chemical Physics"
DOI: 10.1016/j.chemphys.2021.111281
Abstract: Abstract Semi-empirical SCC-DFTB based QM modelling is reported for the active site of human carbonic anhydrase II (HCA II), an enzyme having a rate determining proton transfer reaction with a rate constant of 106 s−1. In… read more here.
Keywords: human carbonic; scc dftb; site; site human ... See more keywords
Molecular modeling studies on the interactions of aflatoxin B1 and its metabolites with the peripheral anionic site of human acetylcholinesterase
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Biomolecular Structure and Dynamics"
DOI: 10.1080/07391102.2018.1475259
Abstract: Abstract Aflatoxins are secondary metabolites of the fungi Aspergillus flavus and A. parasiticus. Among them, aflatoxin B1 (AFB1) is the most frequent type in nature and the most carcinogenic for mammals. It can contaminate many… read more here.
Keywords: peripheral anionic; molecular modeling; anionic site; studies interactions ... See more keywords
Oncogenic lncRNAs alter epigenetic memory at a fragile chromosomal site in human cancer cells
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abl5621
Abstract: Chromosome instability is a critical event in cancer progression. Histone H3 variant CENP-A plays a fundamental role in defining centromere identity, structure, and function but is innately overexpressed in several types of solid cancers. In… read more here.
Keywords: epigenetic memory; oncogenic lncrnas; memory fragile; human cancer ... See more keywords