Crystal Structure of the Cyclostreptin-Tubulin Adduct: Implications for Tubulin Activation by Taxane-Site Ligands
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DOI: 10.3390/ijms20061392
Abstract: It has been proposed that one of the mechanisms of taxane-site ligand-mediated tubulin activation is modulation of the structure of a switch element (the M-loop) from a disordered form in dimeric tubulin to a folded… read more here.
Keywords: taxane; structure; taxane site; tubulin ... See more keywords