Computational Prediction of Site of Metabolism for UGT-Catalyzed Reactions
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DOI: 10.1021/acs.jcim.8b00851
Abstract: The investigation of metabolically liable sites of xenobiotics mediated by UDP-glucuronosyltransferases (UGTs) is important for lead optimization in early drug discovery. However, it is time-consuming and costly to identify potentially susceptible sites experimentally. Hence, in… read more here.
Keywords: metabolism; computational prediction; ugt catalyzed; site metabolism ... See more keywords
Markedly Deranged Injury Site Metabolism and Impaired Functional Recovery in Acute Spinal Cord Injury Patients With Fever
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DOI: 10.1097/ccm.0000000000003134
Abstract: Objectives: To characterize the effect of fever after acute, traumatic spinal cord injury on injury site metabolism and patient outcome. Design: Longitudinal cohort study. In 44 patients (London cohort), we determined the effect of fever… read more here.
Keywords: cord; injury site; site metabolism; injury ... See more keywords