On the Process of Discovering Leads That Target the Heparin-Binding Site of Neutrophil Elastase in the Sputum of Cystic Fibrosis Patients.
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DOI: 10.1021/acs.jmedchem.9b00379
Abstract: Cystic fibrosis (CF) is a disease of dysregulated salt and fluid homeostasis that results in the massive accumulation of neutrophil elastase, resulting in lung degradation and death. The current CF therapy relies on inhaled deoxyribonuclease… read more here.
Keywords: cystic fibrosis; site neutrophil; binding site; elastase ... See more keywords