POST1/C12ORF49 regulates the SREBP pathway by promoting site-1 protease maturation
Sign Up to like & getrecommendations! Published in 2020 at "Protein & Cell"
DOI: 10.1007/s13238-020-00753-3
Abstract: Sterol-regulatory element binding proteins (SREBPs) are the key transcriptional regulators of lipid metabolism. The activation of SREBP requires translocation of the SREBP precursor from the endoplasmic reticulum to the Golgi, where it is sequentially cleaved… read more here.
Keywords: protease; srebp; site protease; c12orf49 ... See more keywords
Site-1 protease controls osteoclastogenesis by mediating LC3 transcription.
Sign Up to like & getrecommendations! Published in 2021 at "Cell death and differentiation"
DOI: 10.1038/s41418-020-00731-6
Abstract: Site-1 protease (S1P) is a Golgi-located protein that activates unique membrane-bound latent transcription factors, and it plays an indispensable role in endoplasmic reticulum stress, lipid metabolism, inflammatory response and lysosome function. A patient with S1P… read more here.
Keywords: s1p; transcription; site protease; osteoclastogenesis ... See more keywords
Site-1 protease function is essential for the generation of antibody secreting cells and reprogramming for secretory activity
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-32705-7
Abstract: The unfolded protein response (UPR) and activation of XBP1 is necessary for high secretory efficiency and functional differentiation of antibody secreting cells (ASCs). The UPR additionally includes a branch in which membrane-bound transcription factors, exemplified… read more here.
Keywords: secreting cells; antibody secreting; secretory; site ... See more keywords
Site-1 protease regulates skeletal stem cell population and osteogenic differentiation in mice
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DOI: 10.1242/bio.032094
Abstract: ABSTRACT Site-1 protease (S1P) is a proprotein convertase with essential functions in the conversion of precursor proteins to their active form. In earlier studies, we demonstrated that S1P ablation in the chondrocyte lineage results in… read more here.
Keywords: bone; site protease; differentiation; mice ... See more keywords
Caspase-11 contributes to site-1 protease cleavage and SREBP1 activation in the inflammatory response of macrophages
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1009973
Abstract: Sterol regulatory element-binding proteins (SREBPs) are key transcription factors that control fatty acid and cholesterol metabolism. As the major SREBP isoform in macrophages, SREBP1a is also required for inflammatory and phagocytotic functions. However, it is… read more here.
Keywords: response macrophages; caspase; site protease; activation ... See more keywords