Controlling the Regioselectivity of Baeyer–Villiger Monooxygenases by Mutation of Active‐Site Residues
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DOI: 10.1002/cbic.201700223
Abstract: Baeyer–Villiger monooxygenase (BVMO)‐mediated regiodivergent conversions of asymmetric ketones can lead to the formation of “normal” or “abnormal” lactones. In a previous study, we were able to change the regioselectivity of a BVMO by mutation of… read more here.
Keywords: site residues; mutation active; baeyer villiger; regioselectivity ... See more keywords
Identification of the active site residues in ATP‐citrate lyase's carboxy‐terminal portion
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DOI: 10.1002/pro.3708
Abstract: ATP‐citrate lyase (ACLY) catalyzes production of acetyl‐CoA and oxaloacetate from CoA and citrate using ATP. In humans, this cytoplasmic enzyme connects energy metabolism from carbohydrates to the production of lipids. In certain bacteria, ACLY is… read more here.
Keywords: site residues; atp citrate; active site; portion ... See more keywords
Theoretical insights on the binding of isoniazid to the active site residues of Mycobacterium tuberculosis catalase-peroxidase.
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DOI: 10.1016/j.tube.2018.11.005
Abstract: Isoniazid (INH) is known to cause the exclusive lethal action to Mycobacterium tuberculosis (M. tb.) cells because of the pathogen's own catalase-peroxidase (katG) enzyme that converts INH to a very reactive radical. Thus, in order… read more here.
Keywords: site residues; active site; catalase; mycobacterium tuberculosis ... See more keywords
The Role of Active-Site Residues Phe98, His239, and Arg243 in DNA Binding and in the Catalysis of Human Uracil–DNA Glycosylase SMUG1
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DOI: 10.3390/molecules24173133
Abstract: Human SMUG1 (hSMUG1) hydrolyzes the N-glycosidic bond of uracil and some uracil lesions formed in the course of epigenetic regulation. Despite the functional importance of hSMUG1 in the DNA repair pathway, the damage recognition mechanism… read more here.
Keywords: site residues; dna; active site; phe98 his239 ... See more keywords
Targeting active site residues and structural anchoring positions in terpene synthases
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DOI: 10.3762/bjoc.17.161
Abstract: The sesterterpene synthase SmTS1 from Streptomyces mobaraensis contains several unusual residues in positions that are otherwise highly conserved. Site-directed mutagenesis experiments for these residues are reported that showed different effects, resulting in some cases in… read more here.
Keywords: site residues; residues structural; active site; terpene synthases ... See more keywords