Site-Selectivity Control in Organic Reactions: A Quest To Differentiate Reactivity among the Same Kind of Functional Groups.
Sign Up to like & getrecommendations! Published in 2017 at "Accounts of chemical research"
DOI: 10.1021/acs.accounts.6b00476
Abstract: On our path to the perfection of organic synthesis lies the challenge of controlling site selectivity, which is the differentiation of reactivity among the same kind of functional groups. Overcoming this challenge would significantly enhance… read more here.
Keywords: among kind; kind functional; reactivity among; site selectivity ... See more keywords
Borane- and Silylium-Catalyzed Difunctionalization of Carbohydrates: 3,6-Anhydrosugar Enabled 1,6-Site Selectivity.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c01243
Abstract: A novel diastereoselective, Lewis acid catalyzed 1,6-difunctionalization of galactose and mannose derivatives has been developed in one pot, via sequential nucleophile additions. Our studies point to the formation of a 3,6-anhydrosugar intermediate as key to… read more here.
Keywords: borane silylium; site selectivity; catalyzed difunctionalization;
Mechanistically Guided Workflow for Relating Complex Reactive Site Topologies to Catalyst Performance in C-H Functionalization Reactions.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.1c12198
Abstract: Leveraging congested catalyst scaffolds has emerged as a key strategy for altering innate substrate site-selectivity profiles in C-H functionalization reactions. Similar to enzyme active sites, optimal small molecule catalysts often feature reactive cavities tailored for… read more here.
Keywords: reactive site; site selectivity; complex reactive; functionalization ... See more keywords
LC–MS/MS-based quantitative study of the acyl group- and site-selectivity of human sirtuins to acylated nucleosomes
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-21060-2
Abstract: Chromatin structure and gene expression are dynamically regulated by posttranslational modifications of histones. Recent advance in mass spectrometry has identified novel types of lysine acylations, such as butyrylation and malonylation, whose functions and regulations are… read more here.
Keywords: acyl group; selectivity; group; site selectivity ... See more keywords
Unique site-selectivity control in asymmetric Michael addition of azlactone to alkenyl dienyl ketones enabled by P-spiro chiral iminophosphorane catalysis.
Sign Up to like & getrecommendations! Published in 2017 at "Chemical communications"
DOI: 10.1039/c7cc01715d
Abstract: A highly regio-, diastereo-, and enantioselective 1,6-addition of azlactone to various alkenyl dienyl ketones has been achieved under P-spiro chiral triaminoiminophosphorane catalysis. This site-selectivity control relies on the distinct ability of the conjugate acids of… read more here.
Keywords: dienyl ketones; spiro chiral; addition azlactone; alkenyl dienyl ... See more keywords
An overview of chemo- and site-selectivity aspects in the chemical conjugation of proteins
Sign Up to like & getrecommendations! Published in 2022 at "Royal Society Open Science"
DOI: 10.1098/rsos.211563
Abstract: The bioconjugation of proteins—that is, the creation of a covalent link between a protein and any other molecule—has been studied for decades, partly because of the numerous applications of protein conjugates, but also due to… read more here.
Keywords: chemo site; overview chemo; site selectivity; conjugation ... See more keywords
Site-selectivity in TBADT-photocatalyzed C(sp3)–H Functionalization of Saturated Alcohols and Alkanes
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DOI: 10.1246/cl.171068
Abstract: Site-selectivity in C(sp3)–H functionalization of aliphatic alcohols and alkanes was studied using the decatungstate anion as a photocatalyst. In the case of aliphatic alcohols, C–H bond α to the hydroxy group was preferentially functionalized. The… read more here.
Keywords: site selectivity; site; alcohols alkanes; sp3 functionalization ... See more keywords
Site Selectivity of Halogen Oxygen Bonding in 5- and 6-Haloderivatives of Uracil
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DOI: 10.3390/cryst9090467
Abstract: Seven 5-and 6-halogenated derivatives of uracil or 1-methyluracil (halogen = Cl, Br, I) were studied by single crystal X-ray diffraction. In contrast with pure 5-halouracils, where the presence of N-H…O and C-H…O hydrogen bonds prevents… read more here.
Keywords: oxygen; halogen oxygen; hydrogen bonds; halogen ... See more keywords
Diverse nucleosome Site-Selectivity among histone deacetylase complexes
Sign Up to like & getrecommendations! Published in 2020 at "eLife"
DOI: 10.7554/elife.57663
Abstract: Histone acetylation regulates chromatin structure and gene expression and is removed by histone deacetylases (HDACs). HDACs are commonly found in various protein complexes to confer distinct cellular functions, but how the multi-subunit complexes influence deacetylase… read more here.
Keywords: site selectivity; nucleosome site; diverse nucleosome; site ... See more keywords