Site‐Specific Polyplex on CCR7 Down‐Regulation and T Cell Elevation for Lymphatic Metastasis Blocking on Breast Cancer
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202201166
Abstract: Tumor metastasis contributes to high cancer mortality. Tumor cells in lymph nodes (LNs) are difficult to eliminate but underlie uncontrollable systemic metastasis. The CC chemokine receptor 7 (CCR7) is overexpressed in tumor cells and interacts… read more here.
Keywords: metastasis; ccr7; tumor cells; site specific ... See more keywords
A Proresolving Peptide Nanotherapy for Site‐Specific Treatment of Inflammatory Bowel Disease by Regulating Proinflammatory Microenvironment and Gut Microbiota
Sign Up to like & getrecommendations! Published in 2019 at "Advanced Science"
DOI: 10.1002/advs.201900610
Abstract: Abstract The incidence and prevalence of inflammatory bowel disease (IBD) increases steadily worldwide. There is an urgent need for effective and safe IBD therapies. Accelerated resolution of inflammation is a new strategy for the management… read more here.
Keywords: bowel disease; inflammatory bowel; site specific; gut microbiota ... See more keywords
Engineering active lysostaphin variants that incorporate noncanonical amino acids and characterizing the effects of site‐specific PEGylation
Sign Up to like & getrecommendations! Published in 2023 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.28360
Abstract: We describe a facile strategy to identify sites for the incorporation of noncanonical amino acids into lysostaphin—an enzyme that degrades the cell wall of Staphylococcus aureus—while retaining stapholytic activity. We used this strategy to generate… read more here.
Keywords: amino acids; lysostaphin variants; site specific; site ... See more keywords
Generation of a host cell line containing a MAR‐rich landing pad for site‐specific integration and expression of transgenes
Sign Up to like & getrecommendations! Published in 2022 at "Biotechnology Progress"
DOI: 10.1002/btpr.3254
Abstract: In recent years, targeted gene integration (TI) has been introduced as a strategy for the generation of recombinant mammalian cell lines for the production of biotherapeutics. Besides reducing the immense heterogeneity within a pool of… read more here.
Keywords: site specific; cell; host cell; specific integration ... See more keywords
A genetic off‐target event in a site‐specific integration cell line expressing monoclonal antibody has no impact on commercial suitability
Sign Up to like & getrecommendations! Published in 2022 at "Biotechnology Progress"
DOI: 10.1002/btpr.3320
Abstract: Site‐specific integration (SSI) cell line systems are gaining popularity for biotherapeutic development and production. Despite the proven advantages for these expression hosts, the SSI system is still susceptible to rare off‐target events and potential vector… read more here.
Keywords: cell; cell line; integration; site specific ... See more keywords
Site‐Specific Incorporation of Chemical Fluorescence on Live Enterovirus‐71 Virion by Using an Organometallic Palladium Reagent To Monitor Virus Entry
Sign Up to like & getrecommendations! Published in 2018 at "ChemBioChem"
DOI: 10.1002/cbic.201800051
Abstract: Imaging live virus to monitor the viral entry process is essential to understand virus–host interactions during pathogen infection. However, methods for efficient labeling of live viruses, in particular labeling non‐enveloped viruses and tracing virus entry… read more here.
Keywords: organometallic palladium; site specific; virus entry; entry ... See more keywords
Site‐Specific Protein Labeling with Fluorophores as a Tool To Monitor Protein Turnover
Sign Up to like & getrecommendations! Published in 2020 at "Chembiochem"
DOI: 10.1002/cbic.201900651
Abstract: Proteins that terminally fail to acquire their native structure are detected and degraded by cellular quality control systems. Insights into cellular protein quality control are key to a better understanding of how cells establish and… read more here.
Keywords: protein; protein turnover; site specific; monitor protein ... See more keywords
Site‐Specific Selenocysteine Incorporation into Proteins by Genetic Engineering
Sign Up to like & getrecommendations! Published in 2021 at "ChemBioChem"
DOI: 10.1002/cbic.202100124
Abstract: Selenocysteine (Sec), a rare naturally proteinogenic amino acid, is the major form of essential trace element selenium in living organisms. Selenoproteins, with one or several Sec residues, are found in all three domains of life.… read more here.
Keywords: selenocysteine incorporation; site specific; specific selenocysteine; incorporation ... See more keywords
Development of a High‐Affinity Antibody‐Binding Peptide for Site‐Specific Modification
Sign Up to like & getrecommendations! Published in 2021 at "ChemMedChem"
DOI: 10.1002/cmdc.202000977
Abstract: Immunoglobulin G (IgG)‐binding peptides such as 15‐IgBP are convenient tools for the site‐specific modification of antibodies and the preparation of homogeneous antibody–drug conjugates. A peptide such as 15‐IgBP can be selectively crosslinked to the fragment… read more here.
Keywords: high affinity; affinity; site specific; specific modification ... See more keywords
Risk of dipeptidyl peptidase‐4 (DPP‐4) inhibitors on site‐specific cancer: A systematic review and meta‐analysis
Sign Up to like & getrecommendations! Published in 2018 at "Diabetes/Metabolism Research and Reviews"
DOI: 10.1002/dmrr.3004
Abstract: The long‐term impact of dipeptidyl peptidase‐4 (DPP‐4) inhibition is unknown, and there are concerns about the influence of DPP‐4 inhibition on carcinogenesis of the pancreas and thyroid. As DPP‐4 is a rather unselective enzyme present… read more here.
Keywords: risk; site specific; dpp inhibitors; specific cancer ... See more keywords
Social environment and genetics underlie body site‐specific microbiomes of Yellowstone National Park gray wolves (Canis lupus)
Sign Up to like & getrecommendations! Published in 2021 at "Ecology and Evolution"
DOI: 10.1002/ece3.7767
Abstract: Abstract The host‐associated microbiome is an important player in the ecology and evolution of species. Despite growing interest in the medical, veterinary, and conservation communities, there remain numerous questions about the primary factors underlying microbiota,… read more here.
Keywords: body site; site specific; genetics; gray wolves ... See more keywords