Selective Antitumor Activity and Photocytotoxicity of Glutathione-Activated Abasic Site Trapping Agents.
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DOI: 10.1021/acschembio.2c00061
Abstract: Abasic (AP) sites are one of the most common DNA lesions in cells. Aldehyde-reactive alkoxyamines capture AP sites and block the activity of APE1, the enzyme responsible for initiating their repair. Blocking the APE1 repair… read more here.
Keywords: cancer; selective antitumor; site trapping; activity ... See more keywords