Development of mAb-based polyglutamine-dependent and polyglutamine length-independent huntingtin quantification assays with cross-site validation
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DOI: 10.1371/journal.pone.0266812
Abstract: Huntington’s disease (HD) is caused by an expansion of the CAG trinucleotide repeat domain in the huntingtin gene that results in expression of a mutant huntingtin protein (mHTT) containing an expanded polyglutamine tract in the… read more here.
Keywords: development; cross site; polyglutamine; site validation ... See more keywords