Sites of chromosomal instability in the context of nuclear architecture and function
Sign Up to like & getrecommendations! Published in 2020 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-020-03698-2
Abstract: Chromosomal fragile sites are described as areas within the tightly packed mitotic chromatin that appear as breaks or gaps mostly tracing back to a loosened structure and not a real nicked break within the DNA… read more here.
Keywords: fragile sites; nuclear architecture; chromosomal instability; instability context ... See more keywords
Fragile sites, chromosomal lesions, tandem repeats, and disease
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2022.985975
Abstract: Expanded tandem repeat DNAs are associated with various unusual chromosomal lesions, despiralizations, multi-branched inter-chromosomal associations, and fragile sites. Fragile sites cytogenetically manifest as localized gaps or discontinuities in chromosome structure and are an important genetic,… read more here.
Keywords: sites chromosomal; chromosomal lesions; repeat; fragile sites ... See more keywords