Replica exchange molecular dynamics simulations reveal self-association sites in M-crystallin caused by mutations provide insights of cataract
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DOI: 10.1038/s41598-021-02728-8
Abstract: Crystallins are ubiquitous, however, prevalence is seen in eye lens. Eye lens crystallins are long-lived and structural intactness is required for maintaining lens transparency and protein solubility. Mutations in crystallins often lead to cataract. In… read more here.
Keywords: replica exchange; eye lens; exchange molecular; sites crystallin ... See more keywords