Discovery of hidden allosteric sites as novel targets for allosteric drug design.
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DOI: 10.1016/j.drudis.2017.10.001
Abstract: Hidden allosteric sites, as a novel type of allosteric site, are invisible in ligand-unbound (apo) crystal structures, but can emerge in ligand-bound (holo) crystal structures when a specific ligand binds to, and stabilizes, a unique… read more here.
Keywords: sites novel; allosteric sites; discovery hidden; drug ... See more keywords