Human cells contain a factor that facilitates the DNA glycosylase-mediated excision of oxidized bases from occluded sites in nucleosomes.
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DOI: 10.1016/j.dnarep.2017.06.029
Abstract: Reactive oxygen species generate some 20,000 base lesions per human cell per day. The vast majority of these potentially mutagenic or cytotoxic lesions are subject to base excision repair (BER). Although chromatin remodelers have been… read more here.
Keywords: sites nucleosomes; excision; dna glycosylase; oxidized bases ... See more keywords