Nanoemulsion‐based electrolyte triggered in situ gel for ocular delivery of acetazolamide
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Pharmaceutical Sciences"
DOI: 10.1016/j.ejps.2017.04.013
Abstract: Abstract In the present work the antiglaucoma drug, acetazolamide, was formulated as an ion induced nanoemulsion‐based in situ gel for ocular delivery aiming a sustained drug release and an improved therapeutic efficacy. Different acetazolamide loaded… read more here.
Keywords: gellan; gel ocular; nanoemulsion; ocular delivery ... See more keywords
Development of in situ gel containing asiaticoside/cyclodextrin complexes. Evaluation in culture human periodontal ligament cells (HPLDCs).
Sign Up to like & getrecommendations! Published in 2020 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2020.119589
Abstract: Asiaticoside (AS), an active herbal compound isolated from Centella asiatica, has the potential benefit in promoting type I collagen (COL I) synthesis and osteogenic differentiation in human periodontal ligament cells (HPDLCs). However, it has low… read more here.
Keywords: periodontal ligament; ligament cells; situ; human periodontal ... See more keywords
Famotidine microspheres reconstituted with floating in situ gel for stomach-specific delivery: Preparation and characterization
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Drug Delivery Science and Technology"
DOI: 10.1016/j.jddst.2017.07.017
Abstract: Abstract Considering the benefits of stomach-specific delivery of H 2 -antagonists, the objective of the present investigation was to develop and characterize a floating in situ gel containing famotidine–chitosan (FM-CS) microspheres. FM-CS microspheres were prepared… read more here.
Keywords: stomach specific; delivery; specific delivery; situ gel ... See more keywords
In-situ gel of nifedipine for preeclampsia: Optimization, in-vitro and in-vivo evaluation
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Drug Delivery Science and Technology"
DOI: 10.1016/j.jddst.2019.01.025
Abstract: Abstract Present study was conducted to develop and optimize in-situ gel for sustained delivery of Nifedipine by ion sensitive mechanism and its in-vitro and in-vivo evaluation. Factorial design was employed to evaluate the effect of… read more here.
Keywords: vivo evaluation; situ; preeclampsia; situ gel ... See more keywords
New HPLC-UV analytical method for quantification of metronidazole: Application to ex vivo ocular kinetic assessments following the administration of thermosensitive ocular in situ gel
Sign Up to like & getrecommendations! Published in 2021 at "Microchemical Journal"
DOI: 10.1016/j.microc.2021.106929
Abstract: Abstract Metronidazole eye drops have been used to treat Acanthamoeba keratitis. However, ophthalmic preparations also have some limitations, one of which is the rapid elimination of the drug, that reducing the effectiveness of the drug.… read more here.
Keywords: thermosensitive ocular; quantification metronidazole; ocular kinetic; ocular situ ... See more keywords
An injectable in situ gel with cubic and hexagonal nanostructures for local treatment of chronic periodontitis
Sign Up to like & getrecommendations! Published in 2017 at "Drug Delivery"
DOI: 10.1080/10717544.2017.1359703
Abstract: Abstract Periodontitis is a chronic bacterial infection, and its effective treatment is dependent on the retention of antibiotics of effective concentrations at the periodontal pockets. In this study, a solution–gel based inverse lyotropic liquid crystalline… read more here.
Keywords: periodontal pockets; treatment; local treatment; situ gel ... See more keywords
Syringeable atorvastatin loaded eugenol enriched PEGylated cubosomes in-situ gel for the intra-pocket treatment of periodontitis: statistical optimization and clinical assessment
Sign Up to like & getrecommendations! Published in 2023 at "Drug Delivery"
DOI: 10.1080/10717544.2022.2162159
Abstract: Abstract Atorvastatin calcium (ATV) is a well-known anti-hyperlipidemic drug currently being recognized for possessing an anti-inflammatory effect. Introducing it as a novel remedy for periodontitis treatment necessitates developing a syringeable modified delivery system capable of… read more here.
Keywords: pegylated cubosomes; enriched pegylated; situ gel; intra pocket ... See more keywords
Evaluations of the Chuanqi Ophthalmic Microemulsion In Situ Gel on Dry Age-Related Macular Degeneration Treatment
Sign Up to like & getrecommendations! Published in 2020 at "Evidence-based Complementary and Alternative Medicine"
DOI: 10.1155/2020/3805967
Abstract: Age-related macular degeneration (AMD) is the third largest eye disease. However, the eye has a variety of drug delivery barriers, which prevent the drug from reaching the lesions in the posterior segment of the eye,… read more here.
Keywords: microemulsion; microemulsion situ; amd; situ gel ... See more keywords
Pullulan and Pluronic F-127 based in situ gel system for intranasal delivery: Development, in vitro and in vivo evaluation
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Bioactive and Compatible Polymers"
DOI: 10.1177/08839115221110284
Abstract: The current work seeks to use Pullulan and Pluronic F-127 (PF-127), a new gel-forming material, for sildenafil citrate (SLC) intranasal delivery. The cold approach was used to develop an SLC-loaded in situ gel based on… read more here.
Keywords: gel; situ gel; pluronic 127; pullulan pluronic ... See more keywords
Sustained release of azithromycin from lipid liquid-crystalline nanoparticles laden in situ gel for the treatment of periodontitis: In vitro and efficacy study
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biomaterials Applications"
DOI: 10.1177/08853282221095395
Abstract: Periodontitis is a chronic inflammatory disease affecting teeth, periodontal ligament and alveolar bone. Current treatment options include surgery or oral antibiotics. Oral dosage forms shows systemic side effects due to frequent dosing and it failed… read more here.
Keywords: situ gel; efficacy; periodontitis; gel ... See more keywords
Development and Evaluation of pH-Responsive Cyclodextrin-Based in situ Gel of Paliperidone for Intranasal Delivery
Sign Up to like & getrecommendations! Published in 2017 at "AAPS PharmSciTech"
DOI: 10.1208/s12249-017-0844-8
Abstract: Paliperidone (PLPD) is approved for treatment and management of schizophrenia. The current study demonstrates the potential of in situ gel of PLPD for nasal delivery. The permeation of drug through sheep nasal mucosa was analyzed… read more here.
Keywords: situ gel; nasal mucosa; delivery; drug ... See more keywords