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   Articles with "situ gel" as a keyword



Lyotropic Liquid Crystalline Based Nasal Spray for Improved Parkinson's Treatment: Enhanced Superior Nasal Tract Deposition and Antioxidation Strategy

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recommendations! Published in 2024 at "Advanced Functional Materials"

DOI: 10.1002/adfm.202411426

Abstract: The blood–brain barrier is one of the serious challenges in the treatment of Parkinson's disease (PD), which severely hinders the drug's brain bioavailability. In this study, a lyotropic liquid crystalline (LLC) based in situ gel… read more here.

Keywords: spray; nasal spray; based situ; gel nasal ... See more keywords

Comprehensive Evaluation and Application of a Hybrid Gel System for Conformance Control in Shinan Reservoir

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recommendations! Published in 2025 at "Journal of Applied Polymer Science"

DOI: 10.1002/app.57171

Abstract: After long‐term production, most mature reservoirs have severe conformance issues, which are extremely difficult to solve by deploying solely gel systems. In this work, we developed a hybrid gel technology for the Shinan oil reservoir,… read more here.

Keywords: hybrid gel; gel; conformance; water ... See more keywords

Nanoemulsion‐based electrolyte triggered in situ gel for ocular delivery of acetazolamide

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recommendations! Published in 2017 at "European Journal of Pharmaceutical Sciences"

DOI: 10.1016/j.ejps.2017.04.013

Abstract: Abstract In the present work the antiglaucoma drug, acetazolamide, was formulated as an ion induced nanoemulsion‐based in situ gel for ocular delivery aiming a sustained drug release and an improved therapeutic efficacy. Different acetazolamide loaded… read more here.

Keywords: gellan; gel ocular; nanoemulsion; ocular delivery ... See more keywords
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Development of in situ gel containing asiaticoside/cyclodextrin complexes. Evaluation in culture human periodontal ligament cells (HPLDCs).

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recommendations! Published in 2020 at "International journal of pharmaceutics"

DOI: 10.1016/j.ijpharm.2020.119589

Abstract: Asiaticoside (AS), an active herbal compound isolated from Centella asiatica, has the potential benefit in promoting type I collagen (COL I) synthesis and osteogenic differentiation in human periodontal ligament cells (HPDLCs). However, it has low… read more here.

Keywords: periodontal ligament; ligament cells; situ; human periodontal ... See more keywords

Famotidine microspheres reconstituted with floating in situ gel for stomach-specific delivery: Preparation and characterization

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recommendations! Published in 2017 at "Journal of Drug Delivery Science and Technology"

DOI: 10.1016/j.jddst.2017.07.017

Abstract: Abstract Considering the benefits of stomach-specific delivery of H 2 -antagonists, the objective of the present investigation was to develop and characterize a floating in situ gel containing famotidine–chitosan (FM-CS) microspheres. FM-CS microspheres were prepared… read more here.

Keywords: stomach specific; delivery; specific delivery; situ gel ... See more keywords

In-situ gel of nifedipine for preeclampsia: Optimization, in-vitro and in-vivo evaluation

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recommendations! Published in 2019 at "Journal of Drug Delivery Science and Technology"

DOI: 10.1016/j.jddst.2019.01.025

Abstract: Abstract Present study was conducted to develop and optimize in-situ gel for sustained delivery of Nifedipine by ion sensitive mechanism and its in-vitro and in-vivo evaluation. Factorial design was employed to evaluate the effect of… read more here.

Keywords: vivo evaluation; situ; preeclampsia; situ gel ... See more keywords

New HPLC-UV analytical method for quantification of metronidazole: Application to ex vivo ocular kinetic assessments following the administration of thermosensitive ocular in situ gel

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recommendations! Published in 2021 at "Microchemical Journal"

DOI: 10.1016/j.microc.2021.106929

Abstract: Abstract Metronidazole eye drops have been used to treat Acanthamoeba keratitis. However, ophthalmic preparations also have some limitations, one of which is the rapid elimination of the drug, that reducing the effectiveness of the drug.… read more here.

Keywords: thermosensitive ocular; quantification metronidazole; ocular kinetic; ocular situ ... See more keywords

Development of synergistic antifungal in situ gel of miconazole nitrate loaded microemulsion as a novel approach to treat vaginal candidiasis

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recommendations! Published in 2024 at "Scientific Reports"

DOI: 10.1038/s41598-024-74021-3

Abstract: Limited solubility is the main cause of the low local availability of anti-candidiasis drug, miconazole nitrate (MN). The study’s objective was to develop and characterize microemulsion (ME) based temperature-triggered in situ gel of MN for… read more here.

Keywords: formulation; miconazole nitrate; nitrate loaded; situ gel ... See more keywords

An injectable in situ gel with cubic and hexagonal nanostructures for local treatment of chronic periodontitis

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recommendations! Published in 2017 at "Drug Delivery"

DOI: 10.1080/10717544.2017.1359703

Abstract: Abstract Periodontitis is a chronic bacterial infection, and its effective treatment is dependent on the retention of antibiotics of effective concentrations at the periodontal pockets. In this study, a solution–gel based inverse lyotropic liquid crystalline… read more here.

Keywords: periodontal pockets; treatment; local treatment; situ gel ... See more keywords

Syringeable atorvastatin loaded eugenol enriched PEGylated cubosomes in-situ gel for the intra-pocket treatment of periodontitis: statistical optimization and clinical assessment

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recommendations! Published in 2023 at "Drug Delivery"

DOI: 10.1080/10717544.2022.2162159

Abstract: Abstract Atorvastatin calcium (ATV) is a well-known anti-hyperlipidemic drug currently being recognized for possessing an anti-inflammatory effect. Introducing it as a novel remedy for periodontitis treatment necessitates developing a syringeable modified delivery system capable of… read more here.

Keywords: pegylated cubosomes; enriched pegylated; situ gel; intra pocket ... See more keywords

Evaluations of the Chuanqi Ophthalmic Microemulsion In Situ Gel on Dry Age-Related Macular Degeneration Treatment

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recommendations! Published in 2020 at "Evidence-based Complementary and Alternative Medicine"

DOI: 10.1155/2020/3805967

Abstract: Age-related macular degeneration (AMD) is the third largest eye disease. However, the eye has a variety of drug delivery barriers, which prevent the drug from reaching the lesions in the posterior segment of the eye,… read more here.

Keywords: microemulsion; microemulsion situ; amd; situ gel ... See more keywords