Effects of persistent modulation of intestinal microbiota on SIV/HIV vaccination in rhesus macaques
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DOI: 10.1038/s41541-021-00298-4
Abstract: An effective vaccine to prevent HIV transmission has not yet been achieved. Modulation of the microbiome via probiotic therapy has been suggested to result in enhanced mucosal immunity. Here, we evaluated whether probiotic therapy could… read more here.
Keywords: modulation; hiv; hiv vaccination; siv hiv ... See more keywords
Genetic adaptations to SIV across chimpanzee populations
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DOI: 10.1371/journal.pgen.1010337
Abstract: Central and eastern chimpanzees are infected with Simian Immunodeficiency Virus (SIV) in the wild, typically without developing acute immunodeficiency. Yet the recent zoonotic transmission of chimpanzee SIV to humans, which were naïve to the virus,… read more here.
Keywords: siv hiv; genetic adaptations; virus; siv ... See more keywords
Transcription Factor ZNF683 Inhibits SIV/HIV Replication through Regulating IFNγ Secretion of CD8+ T Cells
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DOI: 10.3390/v14040719
Abstract: Pulmonary microbial invasion frequently occurs during AIDS progression in HIV patients. Inflammatory cytokines and other immunoregulatory factors play important roles in this process. We previously established an AIDS model of SIVmac239 infection in northern pig-tailed… read more here.
Keywords: factor znf683; ifn secretion; progression; siv hiv ... See more keywords