Antiretroviral therapy restores the homeostatic state of microglia in SIV‐infected rhesus macaques
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.3hi0422-635r
Abstract: Microglia and macrophages are essential for homeostatic maintenance and innate immune response in the brain. They are the first line of defense against infections such as HIV/SIV in the brain. However, they are susceptible to… read more here.
Keywords: state; antiretroviral therapy; brain; state microglia ... See more keywords
CD24 and Fc fusion protein protects SIVmac239‐infected Chinese rhesus macaque against progression to AIDS
Sign Up to like & getrecommendations! Published in 2018 at "Antiviral Research"
DOI: 10.1016/j.antiviral.2018.07.004
Abstract: ABSTRACT Chronic immune activation and systemic inflammation are underlying causes of acquired immunodeficiency syndrome (AIDS). Products of virus replication and microbial translocation, co‐infection or opportunistic pathogens, and danger‐associated molecular patterns have been reported to contribute… read more here.
Keywords: chinese rhesus; progression aids; activation; siv infected ... See more keywords
Mucosal T follicular helper cells in SIV-infected rhesus macaques: contributing role of IL-27
Sign Up to like & getrecommendations! Published in 2019 at "Mucosal Immunology"
DOI: 10.1038/s41385-019-0174-0
Abstract: Mesenteric lymph nodes (MLNs), that drain the large and small intestine, are critical sites for the induction of oral tolerance. Although depletion of CD4 T cells in the intestinal lamina propria is a hallmark of… read more here.
Keywords: tfh cells; rhesus macaques; helper cells; follicular helper ... See more keywords
An SIV-Infected Macaque Model of Enterocytozoon bieneusi Infection.
Sign Up to like & getrecommendations! Published in 2022 at "AIDS research and human retroviruses"
DOI: 10.1089/aid.2022.0091
Abstract: Microsporidiosis caused by E. bieneusi is a common opportunistic infection in patients with HIV/AIDS and those on immunosuppressive therapy. A significant loss of mucosal or peripheral CD4+ T cells and subsequent dysfunction of the intestinal… read more here.
Keywords: cd4; infection; bieneusi infection; siv infected ... See more keywords
Upregulation of Superoxide Dismutase 2 by Astrocytes in the SIV/Macaque Model of HIV-Associated Neurologic Disease.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of neuropathology and experimental neurology"
DOI: 10.1093/jnen/nlaa084
Abstract: HIV-associated neurocognitive disorders (HAND) remain prevalent despite implementation of antiretroviral therapy (ART). Development of HAND is linked to mitochondrial dysfunction and oxidative stress in the brain; therefore, upregulation of antioxidant defenses is critical to curtail… read more here.
Keywords: hiv; macaque model; siv; siv infected ... See more keywords
Host Immunity to Mycobacterium tuberculosis Infection Is Similar in Simian Immunodeficiency Virus (SIV)-Infected, Antiretroviral Therapy-Treated and SIV-Naïve Juvenile Macaques
Sign Up to like & getrecommendations! Published in 2022 at "Infection and Immunity"
DOI: 10.1128/iai.00558-22
Abstract: Pre-existing HIV infection increases tuberculosis (TB) risk in children. Antiretroviral therapy (ART) reduces, but does not abolish, this risk in children with HIV. ABSTRACT Pre-existing HIV infection increases tuberculosis (TB) risk in children. Antiretroviral therapy… read more here.
Keywords: treated siv; tuberculosis; antiretroviral therapy; infection ... See more keywords
Chronic binge alcohol-induced hippocampal plasticity in SIV-infected female rhesus macaques
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5732671
Abstract: Human immunodeficiency virus (HIV) infection is detrimental to central nervous system (CNS) function and may result in HIV-associated neurocognitive disorder (HAND) over time. HIV-associated cognitive deficits are further exacerbated by chronic alcohol use. With the… read more here.
Keywords: female rhesus; rhesus macaques; physiology; siv infected ... See more keywords
Menin mediates Tat-induced neuronal apoptosis in brain frontal cortex of SIV-infected macaques and in Tat-treated cells
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.14993
Abstract: The molecular mechanisms involved in human immunodeficiency virus (HIV)-associated neurocognitive disorder (HAND) remain poorly understood. It has been recently reported that HIV-1 Tat transactivation requires menin, suggesting that menin may be involved in HAND pathogenesis.… read more here.
Keywords: tat induced; menin; neuronal apoptosis; frontal cortex ... See more keywords
Effects of Early Antiretroviral Therapy on the Composition and Diversity of the Fecal Microbiome of SIV-infected Rhesus Macaques (Macaca mulatta).
Sign Up to like & getrecommendations! Published in 2022 at "Comparative medicine"
DOI: 10.30802/aalas-cm-22-000020
Abstract: HIV-infected people develop reproducible disruptions in their gastrointestinal microbiota. Despite the suppression ofHIV viremia via long-term antiretroviral therapy (ART), alterations still occur in gut microbial diversity and the commensal microbiota. Mounting evidence suggests these microbial… read more here.
Keywords: infected rhesus; antiretroviral therapy; infection; diversity ... See more keywords