Installation of a cancer promoting WNT/SIX1 signaling axis by the oncofusion protein MLL-AF9
Sign Up to like & getrecommendations! Published in 2019 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2018.11.039
Abstract: Background Chromosomal translocation-induced expression of the chromatin modifying oncofusion protein MLL-AF9 promotes acute myelocytic leukemia (AML). Whereas WNT/β-catenin signaling has previously been shown to support MLL-AF9-driven leukemogenesis, the mechanism underlying this relationship remains unclear. Methods… read more here.
Keywords: oncofusion protein; six1; wnt; mll af9 ... See more keywords
SIX1 transmits signals for breast cancer progression via the ZEB1/IL6/STAT3 signaling axis
Sign Up to like & getrecommendations! Published in 2025 at "Oncogene"
DOI: 10.1038/s41388-025-03499-6
Abstract: Epithelial-mesenchymal transition (EMT) and breast cancer stem cells (BCSCs) are pivotal in breast cancer mechanism research. It was demonstrated that Sine oculis homeobox homolog 1 (SIX1) orchestrates breast cancer EMT and BCSCs, concurrently activating the… read more here.
Keywords: stat3 signaling; breast cancer; six1;
Unexpected role of SIX1 variants in craniosynostosis: expanding the phenotype of SIX1-related disorders
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Medical Genetics"
DOI: 10.1136/jmedgenet-2020-107459
Abstract: Pathogenic heterozygous SIX1 variants (predominantly missense) occur in branchio-otic syndrome (BOS), but an association with craniosynostosis has not been reported.We investigated probands with craniosynostosis of unknown cause using whole exome/genome (n=628) or RNA (n=386) sequencing,… read more here.
Keywords: six1 variants; role six1; craniosynostosis; six1 ... See more keywords
The SIX1/LDHA Axis Promotes Lactate Accumulation and Leads to NK Cell Dysfunction in Pancreatic Cancer
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Immunology Research"
DOI: 10.1155/2023/6891636
Abstract: Background Pancreatic cancer (PC) is a malignant cancer with poor prognosis and high mortality rate. Sine oculis homeobox homolog 1 (SIX1) participates in the development of many cancers. However, the function of SIX1 in PC… read more here.
Keywords: cell dysfunction; ldha axis; six1; six1 ldha ... See more keywords
Six1 Promotes Epithelial-Mesenchymal Transition in Bronchial Epithelial Cells via the TGFβ1/Smad Signalling Pathway
Sign Up to like & getrecommendations! Published in 2021 at "International Archives of Allergy and Immunology"
DOI: 10.1159/000512873
Abstract: Introduction: The homeodomain transcription factor sine oculis homeobox homolog 1 (Six1) plays a crucial role in embryogenesis and is not expressed in normal adult tissue but is expressed in many pathological processes, including airway remodelling… read more here.
Keywords: smad signalling; tgf smad; six1; signalling pathway ... See more keywords
Sine oculis homeobox homolog 1 plays a critical role in pulmonary fibrosis
Sign Up to like & getrecommendations! Published in 2022 at "JCI Insight"
DOI: 10.1172/jci.insight.142984
Abstract: Idiopathic pulmonary fibrosis (IPF) is a fatal disease with limited treatment options. The role of the developmental transcription factor Sine oculis homeobox homolog 1 (SIX1) in the pathophysiology of lung fibrosis is not known. IPF… read more here.
Keywords: sine oculis; oculis homeobox; lung; pulmonary fibrosis ... See more keywords
Small Molecule Inhibitors of EYA2 Slow Proliferation of SIX1-Expressing Pediatric Leukemias
Sign Up to like & getrecommendations! Published in 2024 at "Blood"
DOI: 10.1182/blood-2024-209244
Abstract: Background: SIX1 is a homeobox gene that is involved in cell proliferation, embryogenesis, and apoptosis. Together with its cofactor Eyes Absent 2 (EYA2), a protein phosphatase, SIX1 transcriptionally activates developmental genes, and is expressed at… read more here.
Keywords: cell lines; six1; leukemia; proliferation ... See more keywords
Inhibition of Six1 affects tumour invasion and the expression of cancer stem cell markers in pancreatic cancer
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DOI: 10.1186/s12885-017-3225-5
Abstract: BackgroundEpithelial-to-mesenchymal transition (EMT) and cancer stem cells (CSC) contribute to tumour progression and metastasis. Assessment of transcription factors involved in these two mechanisms can help to identify new targets for an oncological therapy. In this… read more here.
Keywords: inhibition; pancreatic cancer; six1; expression ... See more keywords
Six1 is essential for differentiation and patterning of the mammalian auditory sensory epithelium
Sign Up to like & getrecommendations! Published in 2017 at "PLoS Genetics"
DOI: 10.1371/journal.pgen.1006967
Abstract: The organ of Corti in the cochlea is a two-cell layered epithelium: one cell layer of mechanosensory hair cells that align into one row of inner and three rows of outer hair cells interdigitated with… read more here.
Keywords: hair cells; hair; six1; differentiation ... See more keywords
Ectomesenchymal Six1 controls mandibular skeleton formation
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2023.1082911
Abstract: Craniofacial development requires intricate cooperation between multiple transcription factors and signaling pathways. Six1 is a critical transcription factor regulating craniofacial development. However, the exact function of Six1 during craniofacial development remains elusive. In this study,… read more here.
Keywords: mandibular skeleton; six1; development; skeleton formation ... See more keywords
LncRNA-Six1 Encodes a Micropeptide to Activate Six1 in Cis and Is Involved in Cell Proliferation and Muscle Growth
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2017.00230
Abstract: Long non-coding RNAs (lncRNAs) play important roles in epigenetic regulation of skeletal muscle development. In our previous RNA-seq study (accession number GSE58755), we found that lncRNA-Six1 is an lncRNA that is differentially expressed between White… read more here.
Keywords: cell proliferation; six1; muscle growth; lncrna six1 ... See more keywords