Sample size calculation for randomized selection trials with a time‐to‐event endpoint and a margin of practical equivalence
Sign Up to like & getrecommendations! Published in 2022 at "Statistics in Medicine"
DOI: 10.1002/sim.9490
Abstract: Selection trials are used to compare potentially active experimental treatments without a control arm. While sample size calculation methods exist for binary endpoints, no such methods are available for time‐to‐event endpoints, even though these are… read more here.
Keywords: size calculation; selection trials; sample size;
Adequate reporting of the sample size calculation in surgical randomized controlled trials.
Sign Up to like & getrecommendations! Published in 2019 at "Surgery"
DOI: 10.1016/j.surg.2019.10.011
Abstract: BACKGROUND The sample size calculation for a randomized controlled trial should assure that a statistically significant and clinically relevant difference can be detected with a high probability. To be certain that readers of a randomized… read more here.
Keywords: randomized controlled; sample size; adequate reporting; size calculation ... See more keywords
Comment on "Long-term Outcome of Surgery Versus Conservative Management for Recurrent and Ongoing Complaints After an Episode of Diverticulitis": Statistically Significant Results Are Not Necessarily Clinically Important.
Sign Up to like & getrecommendations! Published in 2020 at "Annals of Surgery"
DOI: 10.1097/sla.0000000000003809
Abstract: To the Editor: C linical trial results that are statistically significant are routinely considered to be clinically important, and conversely, those with statistically insignificant results are interpreted as being clinically unimportant. However, statistical and clinical… read more here.
Keywords: statistically significant; clinically important; significant results; sample size ... See more keywords
Sample size calculation for agreement between two raters with binary endpoints using exact tests
Sign Up to like & getrecommendations! Published in 2018 at "Statistical Methods in Medical Research"
DOI: 10.1177/0962280216676854
Abstract: In an agreement test between two raters with binary endpoints, existing methods for sample size calculation are always based on asymptotic approaches that use limiting distributions of a test statistic under null and alternative hypotheses.… read more here.
Keywords: raters binary; size; two raters; sample size ... See more keywords
Cardiovascular magnetic resonance feature tracking in small animals – a preliminary study on reproducibility and sample size calculation
Sign Up to like & getrecommendations! Published in 2017 at "BMC Medical Imaging"
DOI: 10.1186/s12880-017-0223-7
Abstract: BackgroundCardiovascular magnetic resonance feature tracking (CMR-FT) is a novel tissue tracking technique developed for noninvasive assessment of myocardial motion and deformation. This preliminary study aimed to evaluate the observer’s reproducibility of CMR-FT in a small… read more here.
Keywords: sample size; size calculation; reproducibility; study ... See more keywords
DELTA2 guidance on choosing the target difference and undertaking and reporting the sample size calculation for a randomised controlled trial
Sign Up to like & getrecommendations! Published in 2018 at "Trials"
DOI: 10.1186/s13063-018-2884-0
Abstract: BackgroundA key step in the design of a RCT is the estimation of the number of participants needed in the study. The most common approach is to specify a target difference between the treatments for… read more here.
Keywords: target difference; sample size; difference; size calculation ... See more keywords
Sample Size Calculation in Genetic Association Studies: A Practical Approach
Sign Up to like & getrecommendations! Published in 2023 at "Life"
DOI: 10.3390/life13010235
Abstract: Genetic association studies, testing the relationship between genetic variants and disease status, are useful tools for identifying genes that grant susceptibility to complex disorders. In such studies, an inadequate sample size may provide unreliable results:… read more here.
Keywords: sample size; genetic association; size; size calculation ... See more keywords