MiCas9 increases large size gene knock-in rates and reduces undesirable on-target and off-target indel edits
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DOI: 10.1038/s41467-020-19842-2
Abstract: Gene editing nuclease represented by Cas9 efficiently generates DNA double strand breaks at the target locus, followed by repair through either the error-prone non-homologous end joining or the homology directed repair pathways. To improve Cas9’s… read more here.
Keywords: knock rates; large size; gene knock; target ... See more keywords