Synthesis of Benzimidazole-Fused Medium-Sized N,S -Heterocycles via Palladium-Catalyzed Cyclizations
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DOI: 10.1002/ejoc.201801686
Abstract: The synthesis of unprecedented benzimidazole-fused thiazocines, thiazonines, and thiazecines having an exocyclic double bond is reported. The process consists in an 8-, 9-, or 10-exo-dig cyclocarbopalladation followed by reduction. The scope and limitations were established… read more here.
Keywords: medium sized; fused medium; sized heterocycles; synthesis benzimidazole ... See more keywords
Synthesis of Medium-Sized Heterocycles by Transition-Metal-Catalyzed Intramolecular Cyclization
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DOI: 10.3390/molecules25143147
Abstract: Medium-sized heterocycles (with 8 to 11 atoms) constitute important structural components of several biologically active natural compounds and represent promising scaffolds in medicinal chemistry. However, they are under-represented in the screening of chemical libraries as… read more here.
Keywords: sized heterocycles; medium sized; metal; synthesis medium ... See more keywords