A happy medium: the synthesis of medicinally important medium-sized rings via ring expansion
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DOI: 10.1039/d0sc00568a
Abstract: Medium-sized rings have much promise in medicinal chemistry, but are difficult to make using direct cyclisation methods. In this minireview, we highlight the value of ring expansion strategies to address this long-standing synthetic challenge. We… read more here.
Keywords: ring expansion; medium; medium sized; synthesis medicinally ... See more keywords
Consecutive Ring-Expansion Reactions for the Iterative Assembly of Medium-Sized Rings and Macrocycles
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DOI: 10.1055/s-0037-1611500
Abstract: Macrocycles and medium-sized rings have important applications in several scientific fields but can be challenging to make using traditional end-to-end cyclization reactions. Ring-expansion methods represent a useful alternative and offer numerous practical benefits. In this… read more here.
Keywords: ring expansion; medium sized; sized rings; consecutive ring ... See more keywords