LAUSR

About LAUSR
Donate
Contact Us

Follow us:

You are not signed in:

Sign Up!


   Articles with "sk2" as a keyword



Lack of UBE3A-Mediated Regulation of Synaptic SK2 Channels Contributes to Learning and Memory Impairment in the Female Mouse Model of Angelman Syndrome

Sign Up to like & get
recommendations! Published in 2022 at "Neural Plasticity"

DOI: 10.1155/2022/3923384

Abstract: Angelman syndrome (AS) is a rare neurodevelopmental disorder characterized by severe developmental delay, motor impairment, language and cognition deficits, and often with increased seizure activity. AS is caused by deficiency of UBE3A, which is both… read more here.

Keywords: female mice; synaptic sk2; sk2; sk2 channels ... See more keywords

Abstract 3995: Investigating the role of sphingosine kinase 2 and p53 in bioprinted head and neck cancer 3D models

Sign Up to like & get
recommendations! Published in 2025 at "Cancer Research"

DOI: 10.1158/1538-7445.am2025-3995

Abstract: Head and neck squamous cell carcinoma (HNSCC) presents a high incidence of recurrences and metastasis. Alterations in sphingolipids metabolism caused by deregulation of sphingosine kinase 2 (SK2) is related to tumor progression. Additionally, the interaction… read more here.

Keywords: cancer; sk2; p53; hnscc ... See more keywords

Muscarinic Modulation of SK2-Type K+ Channels Promotes Intrinsic Plasticity in L2/3 Pyramidal Neurons of the Mouse Primary Somatosensory Cortex

Sign Up to like & get
recommendations! Published in 2020 at "eNeuro"

DOI: 10.1523/eneuro.0453-19.2020

Abstract: Abstract Muscarinic acetylcholine receptors (mAChRs) inhibit small-conductance calcium-activated K+ channels (SK channels) and enhance synaptic weight via this mechanism. SK channels are also involved in activity-dependent plasticity of membrane excitability (“intrinsic plasticity”). Here, we investigate… read more here.

Keywords: mouse primary; plasticity; sk2; intrinsic plasticity ... See more keywords

Synergistic Antiproliferation of Cisplatin and Nitrated [6,6,6]Tricycle Derivative (SK2) for a Combined Treatment of Oral Cancer Cells

Sign Up to like & get
recommendations! Published in 2022 at "Antioxidants"

DOI: 10.3390/antiox11050926

Abstract: SK2, a nitrated [6,6,6]tricycle derivative with an n-butyloxy group, showed selective antiproliferation effects on oral cancer but not on normal oral cells. This investigation assessed for the first time the synergistic antiproliferation potential of cisplatin/SK2… read more here.

Keywords: sk2; oral cancer; cisplatin sk2; antiproliferation ... See more keywords