Lack of UBE3A-Mediated Regulation of Synaptic SK2 Channels Contributes to Learning and Memory Impairment in the Female Mouse Model of Angelman Syndrome
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DOI: 10.1155/2022/3923384
Abstract: Angelman syndrome (AS) is a rare neurodevelopmental disorder characterized by severe developmental delay, motor impairment, language and cognition deficits, and often with increased seizure activity. AS is caused by deficiency of UBE3A, which is both… read more here.
Keywords: female mice; synaptic sk2; sk2; sk2 channels ... See more keywords
Muscarinic Modulation of SK2-Type K+ Channels Promotes Intrinsic Plasticity in L2/3 Pyramidal Neurons of the Mouse Primary Somatosensory Cortex
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DOI: 10.1523/eneuro.0453-19.2020
Abstract: Abstract Muscarinic acetylcholine receptors (mAChRs) inhibit small-conductance calcium-activated K+ channels (SK channels) and enhance synaptic weight via this mechanism. SK channels are also involved in activity-dependent plasticity of membrane excitability (“intrinsic plasticity”). Here, we investigate… read more here.
Keywords: mouse primary; plasticity; sk2; intrinsic plasticity ... See more keywords
Synergistic Antiproliferation of Cisplatin and Nitrated [6,6,6]Tricycle Derivative (SK2) for a Combined Treatment of Oral Cancer Cells
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DOI: 10.3390/antiox11050926
Abstract: SK2, a nitrated [6,6,6]tricycle derivative with an n-butyloxy group, showed selective antiproliferation effects on oral cancer but not on normal oral cells. This investigation assessed for the first time the synergistic antiproliferation potential of cisplatin/SK2… read more here.
Keywords: sk2; oral cancer; cisplatin sk2; antiproliferation ... See more keywords