SK2 channels regulate mitochondrial respiration and mitochondrial Ca2+ uptake
Sign Up to like & getrecommendations! Published in 2017 at "Cell Death and Differentiation"
DOI: 10.1038/cdd.2017.2
Abstract: Mitochondrial calcium ([Ca2+]m) overload and changes in mitochondrial metabolism are key players in neuronal death. Small conductance calcium-activated potassium (SK) channels provide protection in different paradigms of neuronal cell death. Recently, SK channels were identified… read more here.
Keywords: mitochondrial respiration; death; sk2 channels; ca2 uptake ... See more keywords
SK2 channels set a signalling hub bolstering CAF-triggered tumourigenic processes in pancreatic cancer
Sign Up to like & getrecommendations! Published in 2022 at "Gut"
DOI: 10.1136/gutjnl-2021-326610
Abstract: Objective Intercellular communication within pancreatic ductal adenocarcinoma (PDAC) dramatically contributes to metastatic processes. The underlying mechanisms are poorly understood, resulting in a lack of targeted therapy to counteract stromal-induced cancer cell aggressiveness. Here, we investigated… read more here.
Keywords: caf; pancreatic cancer; signalling hub; sk2 channels ... See more keywords
Lack of UBE3A-Mediated Regulation of Synaptic SK2 Channels Contributes to Learning and Memory Impairment in the Female Mouse Model of Angelman Syndrome
Sign Up to like & getrecommendations! Published in 2022 at "Neural Plasticity"
DOI: 10.1155/2022/3923384
Abstract: Angelman syndrome (AS) is a rare neurodevelopmental disorder characterized by severe developmental delay, motor impairment, language and cognition deficits, and often with increased seizure activity. AS is caused by deficiency of UBE3A, which is both… read more here.
Keywords: female mice; synaptic sk2; sk2; sk2 channels ... See more keywords