SK3 Gene Polymorphism Is Associated with Taxane Neurotoxicity and Cell Calcium Homeostasis
Sign Up to like & getrecommendations! Published in 2018 at "Clinical Cancer Research"
DOI: 10.1158/1078-0432.ccr-18-0870
Abstract: Purpose: Taxane-induced peripheral neuropathy is a common side effect induced by anticancer agents, and no drug capable of preventing its occurrence or ameliorating its long-term course has been identified. The physiology of taxane neuropathy is… read more here.
Keywords: homeostasis; sk3; taxane; taxane neurotoxicity ... See more keywords
In silico prediction of the impact of genomic variations in the small conductance calcium activated potassium channel SK3 structure and function
Sign Up to like & getrecommendations! Published in 2025 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2025.1631536
Abstract: The small-conductance calcium-activated potassium channel SK3, encoded by the KCNN3 gene, plays a critical role in regulating dopaminergic neuron (DN) firing patterns by modulating after hyperpolarization currents. SK3 dysfunction has been implicated in neuropsychiatric and… read more here.
Keywords: calcium activated; sk3; activated potassium; conductance calcium ... See more keywords
Short-Term Functional and Morphological Changes in the Primary Cultures of Trigeminal Ganglion Cells
Sign Up to like & getrecommendations! Published in 2022 at "Current Issues in Molecular Biology"
DOI: 10.3390/cimb44030084
Abstract: Several studies have proved that glial cells, as well as neurons, play a role in pain pathophysiology. Most of these studies have focused on the contribution of central glial cells (e.g., microglia and astrocytes) to… read more here.
Keywords: sk3; microscopy; ganglion cells; primary cultures ... See more keywords