Small teleost fish provide new insights into human skeletal diseases.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in cell biology"
DOI: 10.1016/bs.mcb.2016.09.001
Abstract: Small teleost fish such as zebrafish and medaka are increasingly studied as models for human skeletal diseases. Efficient new genome editing tools combined with advances in the analysis of skeletal phenotypes provide new insights into… read more here.
Keywords: small teleost; skeletal diseases; teleost fish; human skeletal ... See more keywords
Nanomaterial-mediated multidimensional regulation of the bone microenvironment: a precise therapeutic strategy for bone metabolic imbalance.
Sign Up to like & getrecommendations! Published in 2025 at "Drug delivery"
DOI: 10.1080/10717544.2025.2595324
Abstract: ABSTRACT With the advancement of global population aging, the incidence of skeletal diseases (e.g. osteoporosis, fractures, and osteoarthritis) in clinical diagnosis increases and poses a serious threat to human health. Skeletal diseases usually occur as… read more here.
Keywords: bone microenvironment; regulation bone; bone; therapeutic strategy ... See more keywords
Emerging Potential Therapeutic Targets of Ferroptosis in Skeletal Diseases
Sign Up to like & getrecommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2022/3112388
Abstract: Ferroptosis is a new programmed cell death characterized by the accumulation of lipid peroxidation mediated by iron and inflammation. Since the transcentury realization of ferroptosis as an iron-dependent modality of nonapoptotic cell death in 2012,… read more here.
Keywords: cell death; potential therapeutic; skeletal diseases; ferroptosis ... See more keywords
The Molecular Structure and Role of Humanin in Neural and Skeletal Diseases, and in Tissue Regeneration
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.823354
Abstract: Humanin (HN) belongs to a member of mitochondrial-derived peptides (MDPs) which are encoded by mitochondrial genes. HN shares sequence homology with thirteen HN-like proteins, named MTRNR2L1 to MTRNR2L13, which encompass 24–28 amino acid residues in… read more here.
Keywords: neural skeletal; role; tissue regeneration; skeletal diseases ... See more keywords
Skeletal diseases caused by mutations in PTH1R show aberrant differentiation of skeletal progenitors due to dysregulation of DEPTOR
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.963389
Abstract: Alterations in the balance between skeletogenesis and adipogenesis is a pathogenic feature in multiple skeletal disorders. Clinically, enhanced bone marrow adiposity in bones impairs mobility and increases fracture risk, reducing the quality of life of… read more here.
Keywords: differentiation skeletal; skeletal progenitors; show; differentiation ... See more keywords
Therapeutic potential of mesenchymal stem cell-derived exosomes in skeletal diseases
Sign Up to like & getrecommendations! Published in 2024 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2024.1268019
Abstract: Skeletal diseases impose a considerable burden on society. The clinical and tissue-engineering therapies applied to alleviate such diseases frequently result in complications and are inadequately effective. Research has shifted from conventional therapies based on mesenchymal… read more here.
Keywords: mesenchymal stem; derived exosomes; therapeutic potential; exosomes skeletal ... See more keywords
Sp7 Action in the Skeleton: Its Mode of Action, Functions, and Relevance to Skeletal Diseases
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23105647
Abstract: Osteoblast differentiation is a tightly regulated process in which key transcription factors (TFs) and their target genes constitute gene regulatory networks (GRNs) under the control of osteogenic signaling pathways. Among these TFs, Sp7 works as… read more here.
Keywords: relevance; sp7 action; action; skeleton ... See more keywords